University of Oulu

Meri-Maija Ollila, Terhi T. Piltonen, Juha S. Tapanainen, Laure Morin-Papunen, Aging women with polycystic ovary syndrome: menstrual cycles, metabolic health, and health-related quality of life, Current Opinion in Endocrine and Metabolic Research, Volume 12, 2020, Pages 14-19, ISSN 2451-9650,

Aging women with polycystic ovary syndrome : menstrual cycles, metabolic health, and health-related quality of life

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Author: Ollila, Meri-Maija1; Piltonen, Terhi T.1; Tapanainen, Juha S.1,2;
Organizations: 1Department of Obstetrics and Gynaecology, University of Oulu and Oulu University Hospital, Medical Research Centre, PEDEGO Research Unit, P.O. BOX 23, FI-90029, Oulu, Finland
2Department of Obstetrics and Gynaecology, University of Helsinki and Helsinki University Hospital, P.O. BOX 63, FI-00014, Helsinki, Finland
Format: article
Version: accepted version
Access: open
Online Access: PDF Full Text (PDF, 0.6 MB)
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Language: English
Published: Elsevier, 2020
Publish Date: 2021-02-28


Women with polycystic ovary syndrome (PCOS) in their reproductive years present with metabolic dysfunction and thus increased likelihood of long-term health consequences and diminished well-being in later life. Owing to their larger ovarian reserve, however, they may experience menopause at later age and protection from metabolic and cardiovascular diseases. Moreover, previous studies have indicated that late reproductive-aged, normal-weight women with PCOS do not seem to have the expected high risk for type 2 diabetes (T2D), as previously thought. Health-related quality of life, nevertheless, is decreased in women with PCOS up until late fertile age, warranting attention and actions from the health care personnel. Given conflicting reports regarding the risk of cardiovascular diseases, future research with well characterized and adequately sized PCOS populations are needed, as well as studies aiming to improve their health-related quality of life.

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Series: Current opinion in endocrine and metabolic research
ISSN: 2451-9650
ISSN-E: 2451-9650
ISSN-L: 2451-9650
Volume: 12
Pages: 14 - 19
DOI: 10.1016/j.coemr.2020.02.010
Type of Publication: A2 Review article in a scientific journal
Field of Science: 3123 Gynaecology and paediatrics
Funding: This work was supported by research grants from the Sigrid Jusélius Foundation, Academy of Finland, Finnish Medical Foundation, Oulu University Hospital and Helsinki University Hospital.
Copyright information: © 2020 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0 license