University of Oulu

Zhu, R., Avsievich, T., Popov, A., & Meglinski, I. (2020). Optical Tweezers in Studies of Red Blood Cells. Cells, 9(3), 545. doi:10.3390/cells9030545

Optical tweezers in studies of red blood cells

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Author: Zhu, Ruixue1; Avsievich, Tatiana1; Popov, Alexey1;
Organizations: 1Optoelectronics and Measurement Techniques Laboratory, University of Oulu, 90570 Oulu, Finland
2Interdisciplinary Laboratory of Biophotonics, National Research Tomsk State University, 634050 Tomsk, Russia
3Institute of Engineering Physics for Biomedicine (PhysBio), National Research Nuclear University (MEPhI), 115409 Moscow, Russia
4Aston Institute of Materials Research, School of Engineering and Applied Science, Aston University, Birmingham B4 7ET, UK
5School of Life and Health Sciences, Aston University, Birmingham B4 7ET, UK
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 9 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe2020051938295
Language: English
Published: Multidisciplinary Digital Publishing Institute, 2020
Publish Date: 2020-05-19
Description:

Abstract

Optical tweezers (OTs) are innovative instruments utilized for the manipulation of microscopic biological objects of interest. Rapid improvements in precision and degree of freedom of multichannel and multifunctional OTs have ushered in a new era of studies in basic physical and chemical properties of living tissues and unknown biomechanics in biological processes. Nowadays, OTs are used extensively for studying living cells and have initiated far-reaching influence in various fundamental studies in life sciences. There is also a high potential for using OTs in haemorheology, investigations of blood microcirculation and the mutual interplay of blood cells. In fact, in spite of their great promise in the application of OTs-based approaches for the study of blood, cell formation and maturation in erythropoiesis have not been fully explored. In this review, the background of OTs, their state-of-the-art applications in exploring single-cell level characteristics and bio-rheological properties of mature red blood cells (RBCs) as well as the OTs-assisted studies on erythropoiesis are summarized and presented. The advance developments and future perspectives of the OTs’ application in haemorheology both for fundamental and practical in-depth studies of RBCs formation, functional diagnostics and therapeutic needs are highlighted.

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Series: Cells
ISSN: 2073-4409
ISSN-E: 2073-4409
ISSN-L: 2073-4409
Volume: 9
Issue: 3
Article number: 545
DOI: 10.3390/cells9030545
OADOI: https://oadoi.org/10.3390/cells9030545
Type of Publication: A2 Review article in a scientific journal
Field of Science: 222 Other engineering and technologies
1182 Biochemistry, cell and molecular biology
Subjects:
Funding: This research was partially supported by China Scholarship Council (CSC No. 201706410089, R.Z.), Tauno Tönning Foundation (grant No. 20190104, R.Z.), EDUFI Fellowship (TM-17-10370, TM-18-10820, T.A.) and Suomen Kulttuurirahasto (grant No. 00190188, T.A.). The authors also acknowledge the contribution of Russian Science Foundation (Project19-72-3001). I.M. acknowledges partial support from the Academy of Finland (project 326204, 325097), MEPhI Academic Excellence Project (Contract No. 02.a03.21.0005) and the National Research Tomsk State University Academic D.I. Mendeleev Fund Program.
Academy of Finland Grant Number: 326204
325097
Detailed Information: 326204 (Academy of Finland Funding decision)
325097 (Academy of Finland Funding decision)
Copyright information: © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
  https://creativecommons.org/licenses/by/4.0/