University of Oulu

Pasma, H, Honkila, M, Pokka, T, Renko, M, Salo, E, Tapiainen, T. Epidemiology of Kawasaki disease before and after universal Bacille Calmette‐Guérin vaccination program was discontinued. Acta Paediatr. 2020; 109: 842– 846. https://doi.org/10.1111/apa.15012

Epidemiology of Kawasaki disease before and after universal Bacille Calmette‐Guérin vaccination program was discontinued

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Author: Pasma, Hanna1; Honkila, Minna1,2; Pokka, Tytti1,2;
Organizations: 1PEDEGO Research Unit and Medical Research Center Oulu, University of Oulu, Oulu, Finland
2Department of Pediatrics and Adolescence, Oulu University Hospital, Oulu, Finland
3Department of Pediatrics, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland
4Children's Hospital, Helsinki University Hospital and University of Helsinki, Helsinki, Finland
Format: article
Version: accepted version
Access: open
Online Access: PDF Full Text (PDF, 0.6 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe2020051938370
Language: English
Published: John Wiley & Sons, 2020
Publish Date: 2020-09-13
Description:

Abstract

Aim: Bacille Calmette‐Guérin (BCG) vaccine (BCG) has been suggested to induce the primary immunity needed for the subsequent Kawasaki disease (KD). We studied the epidemiology of KD before and after the universal BCG vaccination ended in Finland in September 2006.

Methods: Kawasaki disease cases were retrieved from national health registries from 1996 to 2016 for annual incidence rates. We then compared 612 433 children born in the BCG vaccination era, from 1 January 1996 to 30 August 2006, to 604 163 born after BCG era, from 1 September 2006 to 31 December 2016.

Results: The annual incidence rates did not change after the BCG vaccination stopped. We found 370 first visits for KD by children born in the BCG era and 341 after universal BCG vaccination ended. The mean age at diagnosis increased from 2.6 years to 3.0 years (95% CI−0.64 to −0.012, P = .04) and the proportion of children with Kawasaki disease under 5 years decreased from 87% to 81% (95% CI 1%‐12%, P = .02).

Conclusions: Discontinuing the universal BCG vaccination programme did not change the incidence rates of KD. The increased age at diagnosis could suggest that the pathogenesis of KD may be associated with the immunological pathways primed by BCG immunisation.

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Series: Acta pædiatrica
ISSN: 0803-5253
ISSN-E: 1651-2227
ISSN-L: 0803-5253
Volume: 109
Issue: 4
Pages: 842 - 846
DOI: 10.1111/apa.15012
OADOI: https://oadoi.org/10.1111/apa.15012
Type of Publication: A1 Journal article – refereed
Field of Science: 3123 Gynaecology and paediatrics
Subjects:
Copyright information: © 2019 Foundation Acta Pædiatrica. Published by John Wiley & Sons Ltd. This is the peer reviewed version of the following article: [Pasma, H, Honkila, M, Pokka, T, Renko, M, Salo, E, Tapiainen, T. Epidemiology of Kawasaki disease before and after universal Bacille Calmette‐Guérin vaccination program was discontinued. Acta Paediatr. 2020; 109: 842– 846, which has been published in final form at https://doi.org/10.1111/apa.15012. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.