University of Oulu

Sarala, M., Miettunen, J., Koskela, J., Mustonen, A., Rose, R. J., Hurtig, T., Veijola, J., and Niemelä, S. ( 2020) Frequent intoxication and alcohol tolerance in adolescence: associations with psychiatric disorders in young adulthood. Addiction, 115: 888– 900. https://doi.org/10.1111/add.14889

Frequent intoxication and alcohol tolerance in adolescence : associations with psychiatric disorders in young adulthood

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Author: Sarala, Marian1; Miettunen, Jouko2,3; Koskela, Jari1;
Organizations: 1Research Unit of Clinical Neuroscience, University of Oulu, Oulu, Finland
2Center for Life Course Health Research, University of Oulu, Oulu, Finland
3Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland
4Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN, USA
5PEDEGO Research Unit, Child Psychiatry, University of Oulu, Oulu, Finland
6Clinic of Child Psychiatry, Oulu University Hospital, Oulu, Finland
7Department of Psychiatry, Oulu University Hospital, Oulu, Finland
8Department of Psychiatry, University of Turku, Turku, Finland
9Addiction Psychiatry Unit, Department of Psychiatry, Hospital District of Southwest Finland, Turku, Finland
Format: article
Version: accepted version
Access: embargoed
Persistent link: http://urn.fi/urn:nbn:fi-fe2020060140016
Language: English
Published: John Wiley & Sons, 2020
Publish Date: 2020-11-22
Description:

Abstract

Aims: To assess the associations of intoxication frequency and number of drinks needed to become intoxicated in mid‐adolescence with onset of psychiatric disorders in early adulthood.

Design, Setting and Participants: Prospective cohort study in Northern Finland, with people from the Northern Finland Birth Cohort 1986 who self‐reported adolescent alcohol use: 6548 subjects (69.4% of the original sample). Data on alcohol use were collected using questionnaires at ages 15–16 years.

Measurements: Outcomes were any non‐organic psychosis, mood disorder, anxiety disorder, any substance use disorder (SUD) and all the studied psychiatric disorders in early adulthood gathered from nation‐wide health care, pension and insurance registers. Number of drinks needed to become intoxicated was categorized into three classes: (1) no alcohol use or intoxication, and (2) low and (3) high alcohol tolerance (more than seven/nine drinks for females/males) groups. Similarly, intoxication frequency was divided into three classes: (1) never, (2) one to two times and (3) three or more times during the past 30 days. Information regarding gender, family type, other drug use, psychopathology using Youth Self‐Report (YSR) total score and parental psychiatric disorders were used as covariates.

Findings: In the multivariable analyses, both low [odds ratio (OR) = 3.0, 95% confidence interval (CI) = 1.3–6.7, P‐value = 0.009] and high (OR = 4.4, 95% CI = 1.8–11.1, P‐value = 0.001) alcohol tolerance were associated with increased risk of SUD. More frequent intoxication was associated with increased frequency of SUD (OR = 3.9, 95% CI = 2.0–7.3, P‐value < 0.001) and mood disorder (OR = 1.6, 95% CI = 1.1–2.3, P‐value = 0.008). The latter was attenuated after adjusting with concurrent psychopathology (YSR) and other drug use.

Conclusions: Both higher alcohol tolerance and frequent intoxication in adolescence appear to be associated with increased risk of future substance use disorder.

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Series: Addiction
ISSN: 0965-2140
ISSN-E: 1360-0443
ISSN-L: 0965-2140
Volume: 115
Issue: 5
Pages: 888 - 900
DOI: 10.1111/add.14889
OADOI: https://oadoi.org/10.1111/add.14889
Type of Publication: A1 Journal article – refereed
Field of Science: 3124 Neurology and psychiatry
Subjects:
Funding: This research was funded by the Juho Vainio Foundation, Sohlberg Foundation and State Research Funding.
Copyright information: © 2019 Society for the Study of Addiction. This is the peer reviewed version of the following article: Sarala, M., Miettunen, J., Koskela, J., Mustonen, A., Rose, R. J., Hurtig, T., Veijola, J., and Niemelä, S. ( 2020) Frequent intoxication and alcohol tolerance in adolescence: associations with psychiatric disorders in young adulthood. Addiction, 115: 888– 900, which has been published in final form at https://doi.org/10.1111/add.14889. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving