Viktor Dremin, Dmytro Anin, Oleksii Sieryi, Mariia Borovkova, Juha Näpänkangas, Igor Meglinski, and Alexander Bykov "Imaging of early stage breast cancer with circularly polarized light", Proc. SPIE 11363, Tissue Optics and Photonics, 1136304 (7 April 2020); https://doi.org/10.1117/12.2554166
Imaging of early stage breast cancer with circularly polarized light
|Author:||Dremin, Viktor1,2; Anin, Dmytro1; Sieryi, Oleksii1;|
1Optoelectronics and Measurement Techniques Unit, University of Oulu, Oulu, Finland
2Research & Development Center of Biomedical Photonics, Orel State University, Orel, Russia
3Oulu University Hospital, University of Oulu, Oulu, Finland
4School of Engineering & Applied Science, Aston University, Birmingham, UK
5School of Life & Health Sciences, Aston University, Birmingham, UK
|Online Access:||PDF Full Text (PDF, 0.7 MB)|
|Persistent link:|| http://urn.fi/urn:nbn:fi-fe2020060240143
|Publish Date:|| 2020-06-02
In this study, we utilize the properties of polarized light for the analysis of paraffin-embedded breast cancer samples. We perform the measurements of the full Stokes vector of back-reflected radiation and calculate the degree of polarization as a diagnostic criterion for the separation of healthy and cancer sample sections. We show that circularly polarized light scattered within the breast sample is sensitive to the presence of cancer cells. The degree of the polarization of the reflected light was found to be the most sensitive parameter for the reliable differentiation of tissue. We show that circularly polarized light scattered within the breast sample is sensitive to the presence of cancer cells. The highest contrast between cancerous and normal regions was observed for the probing wavelength of 450 nm. The degree of the polarization of the reflected light was found to be the most sensitive parameter. Mapping the Stokes vectors of backscattered light on a Poincaré sphere helps to highlight the changes of polarization state.
Proceedings of SPIE
Proceedings Volume 11363, Tissue Optics and Photonic. SPIE Photonics Europe, 2020
|Host publication editor:||
Tuchin, Valery V.
Blondel, Walter C. P. M.
SPIE Photonics Europe
|Type of Publication:||
B3 Article in conference proceedings
|Field of Science:||
114 Physical sciences
Authors acknowledge the support of the Academy of Finland (grants: 314369 and 325097), the ATTRACT project funded by the EU under Grant Agreement 777222. This study was also supported by the Russian Science Foundation under projects No. 19-79-00082 (experimental data collection). Authors acknowledge Northern Finland Biobank Borealis, Oulu, Finland (www.ppshp.fi/biopankki) for providing the breast cancer samples.
|Academy of Finland Grant Number:||
314369 (Academy of Finland Funding decision)
325097 (Academy of Finland Funding decision)
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