Mariia Borovkova, Alexander Bykov, Alexey Popov, Angelo Pierangelo, Tatiana Novikova, Jens Pahnke, and Igor Meglinski "The use of Stokes-Mueller polarimetry for assessment of amyloid-β progression in a mouse model of Alzheimer’s disease", Proc. SPIE 11234, Optical Biopsy XVIII: Toward Real-Time Spectroscopic Imaging and Diagnosis, 112340M (21 February 2020); https://doi.org/10.1117/12.2550795
The use of Stokes-Mueller polarimetry for assessment of amyloid-β progression in a mouse model of Alzheimer’s disease
|Author:||Borovkova, Mariia1; Bykov, Alexander1; Popov, Alexey1;|
1Optoelectronics and Measurement Techniques unit, University of Oulu, Oulu 90570, Finland
2LPICM, Ecole polytechnique, Route de Saclay, Palaiseau 91128, France
3Department of Neuro-/Pathology, University of Oslo & Oslo University Hospital, Oslo, Norway
4LIED, University of Lübeck, Ratzeburger Allee 160, 23562 Lübeck, Germany
5Department of Pharmacology, Medical Faculty, University of Latvia, LV-1004 Riga, Latvia
6School of Engineering and Applied Science, Aston University, Aston St, Birmingham B4 7ET, UK
7School of Life and Health Sciences, Aston University, Aston St, Birmingham B4 7ET, UK
|Online Access:||PDF Full Text (PDF, 0.9 MB)|
|Persistent link:|| http://urn.fi/urn:nbn:fi-fe2020060340266
|Publish Date:|| 2020-06-03
Alzheimer’s disease, being a major societal burden, demands improvement of current techniques for its treatment and diagnostics. Currently only autopsy histology is able to provide the definite diagnosis for Alzheimer’s disease. However, the procedure is rather time consuming and costly. In the current study, we utilized Stokes and Mueller polarimetry techniques to screen for amyloid-β (Aβ) deposits in formalin-fixed, paraffin-embedded mouse brain tissue at different stages of Alzheimer’s disease. The study has shown that the presence of Aβ plaques influences the properties of scattered polarized light. The Poincaré sphere was used as a graphical tool for the visualization of the alterations of the Stokes vector, obtained with Stokes polarimetry, whereas statistical moments were used for the analysis of depolarization distributions that were acquired with Mueller polarimetry. We demonstrate the sensitivity of the last component of the Stokes vector, the degree of polarization and high-order statistical moments of depolarization to the structural alterations in brain tissue, which correspond to the disease progression. The described approach has a potential to improve the existing pathology screening methods and facilitates Aβ detection in AD research.
Progress in biomedical optics and imaging
Optical Biopsy XVIII: Toward Real-Time Spectroscopic Imaging and Diagnosis. 1-6 Feb 2020, San Francisco, USA
|Host publication editor:||
Alfano, Robert R.
Demos, Stavros G.
Seddon, Angela B.
|Type of Publication:||
B3 Article in conference proceedings
|Field of Science:||
114 Physical sciences
This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No.713606, Cost Actions CA16118, the ATTRACT project funded by the EC under Grant Agreement 777222, Academy of Finland (grants: 314369 and 325097), and INFOTECH strategic funding. The work of J.P. was supported by the following grants: Deutsche Forschungsgemeinschaft/ Germany (DFG PA930/12); Wirtschaftsministerium Sachen-Anhalt (EFRE, ZS/2016/05/78617) and the Leibniz Association (Leibniz-Wettbewerb SAW-2015-IPB-2); Latvian Council of Science FLPP/ Latvia (lzp-2018/1-0275); Nasjonalforeningen (16154), HelseSØ/ Norway (2016062, 2019054, 2019055); Norsk forskningsrådet/ Norway (251290 FRIMEDIO, 260786 PROP-AD); Horizon 2020/ European Union (643417 (PROP-AD)). PROP-AD is an EU Joint Programme - Neurodegenerative Disease Research (JPND) project. The project is supported through the following funding organisations under the aegis of JPND - www.jpnd.eu (AKA, no.301228 – Finland , BMBF #01ED1605- Germany, CSO-MOH #30000-12631 - Israel, NFR #260786 - Norway, SRC #2015-06795 - Sweden). This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement #643417 (JPco-fuND).
|EU Grant Number:||
(713606) I4FUTURE - Novel Imaging and Characterisation Methods in Bio, Medical, and Environmental Research and Technology Innovations
|Academy of Finland Grant Number:||
314369 (Academy of Finland Funding decision)
325097 (Academy of Finland Funding decision)
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