University of Oulu

Ojwang, V, Nwaru, BI, Takkinen, H‐M, et al. Early exposure to cats, dogs and farm animals and the risk of childhood asthma and allergy. Pediatr Allergy Immunol. 2020; 31: 265– 272. https://doi.org/10.1111/pai.13186

Early exposure to cats, dogs and farm animals and the risk of childhood asthma and allergy

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Author: Ojwang, Vincent1,2; Nwaru, Bright I.1,3,4; Takkinen, Hanna-Mari1,5;
Organizations: 1Faculty of Social Sciences/Health Sciences, Tampere University, Tampere, Finland
2Center for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya
3Krefting Research Centre, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden
4Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, Gothenburg, Sweden
5Department of Public Health Solutions, National Institute for Health and Welfare, Helsinki, Finland
6Department of Pediatrics, Tampere University Hospital, Tampere, Finland
7Public Health Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
8Department of Laboratory Medicine, Medical Research Unit, Seinajoki Central Hospital, Tampere University, Tampere, Finland
9Fimlab Laboratories, Pirkanmaa Hospital District, Tampere, Finland
10Immunogenetics Laboratory, Institute of Biomedicine, University of Turku, Turku, Finland
11Department of Clinical Microbiology, Turku University Hospital, Turku, Finland
12Institute of Biomedicine, Research Centre of Integrative Physiology and Pharmacology, University of Turku, Turku, Finland
13Department of Pediatrics, Turku University Hospital, Turku, Finland
14Department of Virology, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland
15Department of Pediatrics, PEDEGO Research Unit, Medical Research Centre, Oulu University Hospital, University of Oulu, Oulu, Finland
16Tampere Center for Child Health Research, Tampere University Hospital, Tampere University, Tampere, Finland
17Science Center of Pirkanmaa Hospital District, Tampere, Finland
18Folkhalsan Research Center, Helsinki, Finland
19Children’s Hospital, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland
20Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland
21Science Centre, Tampere University Hospital, Tampere, Finland
Format: article
Version: accepted version
Access: embargoed
Persistent link: http://urn.fi/urn:nbn:fi-fe2020060440747
Language: English
Published: John Wiley & Sons, 2020
Publish Date: 2020-12-12
Description:

Abstract

Background: Synergistic role of exposure to cats, dogs, and farm animals during infancy on the risk of childhood asthma and allergy remains unknown.

Objectives: To investigate independent and synergistic associations between exposure to indoor pets and farm animals during infancy and the risk of asthma and allergy by age 5.

Methods: We studied 3781 children participating in the Finnish Type 1 Diabetes Prediction and Prevention (DIPP) Nutrition Study. At age 5, a validated version of the International Study of Asthma and Allergies in Childhood questionnaire was administered to collect information on asthma and allergic disease, and exposure to indoor pets and farm animals during the first year of life. Allergen‐specific IgE antibodies were analyzed from serum samples. Statistical analyses employed Cox proportional hazards and logistic regression.

Results: Having a dog in the house was inversely associated with the risk of asthma (HR 0.60; 95% CI, 0.38‐0.96), allergic rhinitis (OR 0.72; 95% CI, 0.53‐0.97), and atopic sensitization (OR 0.77; 95% CI, 0.63‐0.96). Having a cat was associated with a decreased risk of atopic eczema (OR 0.68; 95% CI, 0.51‐0.92). Farm animals were neither independently nor in synergy with indoor pets associated with the outcomes.

Conclusion: Having a dog or cat in the house during the first year of life may protect against childhood asthma and allergy. We did not find a synergistic association between cat, dog, and farm animal exposure on the risk of childhood asthma and allergy. Future research should identify specific causative exposures conferred by indoor pets and whether they could be recommended for allergy prevention.

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Series: Pediatric allergy and immunology
ISSN: 0905-6157
ISSN-E: 1399-3038
ISSN-L: 0905-6157
Volume: 31
Issue: 3
Pages: 265 - 272
DOI: 10.1111/pai.13186
OADOI: https://oadoi.org/10.1111/pai.13186
Type of Publication: A1 Journal article – refereed
Field of Science: 3121 General medicine, internal medicine and other clinical medicine
3123 Gynaecology and paediatrics
Subjects:
Funding: The study was supported by funding from the Academy of Finland (Grants 44105, 48724, 80846, 201988, 126813, 129492, and 276475); the Prevaller Consortium; the Foundation for Pediatric Research; the Tampere Tuberculosis Foundation; the Juho Vainio Foundation; the Yrjo Jahnsson Foundation; Medical Research Funds, Turku and Oulu University Hospitals; the Competitive State Research Financing of the Expert Responsibility area of Tampere University Hospital (Grants 9K045, 9K149, 9L035, 9L117, 9M036, 9M114, 9P017, 9P057, 9R012, 9R055, 9S015, 9S074, 9T013, 9T072, 9U016, and 9U065); the Juvenile Diabetes Research Foundation; the Novo Nordisk Foundation; and the EU Biomed 2 Program (BMH4‐CT98‐3314).
Academy of Finland Grant Number: 126813
129492
276475
Detailed Information: 126813 (Academy of Finland Funding decision)
129492 (Academy of Finland Funding decision)
276475 (Academy of Finland Funding decision)
Copyright information: © 2019 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd. This is the peer reviewed version of the following article: Ojwang, V, Nwaru, BI, Takkinen, H‐M, et al. Early exposure to cats, dogs and farm animals and the risk of childhood asthma and allergy. Pediatr Allergy Immunol. 2020; 31: 265– 272, which has been published in final form at https://doi.org/10.1111/pai.13186. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.