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Bello, IO, Almangush, A, Heikkinen, I, et al. Histological characteristics of early‐stage oral tongue cancer in young versus older patients: A multicenter matched‐pair analysis. Oral Dis. 2020; 26: 1081– 1085. https://doi.org/10.1111/odi.13288

Histological characteristics of early‐stage oral tongue cancer in young versus older patients : a multicenter matched‐pair analysis

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Author: Bello, Ibrahim O.1,2; Almangush, Alhadi2,3,4; Heikkinen, Ilkka2;
Organizations: 1Department of Oral Medicine and Diagnostic Sciences, King Saud University, Riyadh, Saudi Arabia
2Department of Pathology, University of Helsinki, Helsinki, Finland
3Institute of Biomedicine, Pathology, University of Turku, Turku, Finland
4Faculty of Dentistry, University of Misurata, Misurata, Libya
5Research Programs Unit, Translational Cancer Biology, University of Helsinki, Helsinki, Finland
6Department of Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
7Department of Oral Diagnosis, School of Dentistry, University of Campinas, Piracicaba, São Paulo, Brazil
8Department of Head and Neck Surgery and Otorhinolaryngology, AC Carmago Cancer Center, Sao Paulo, Brazi
9Head and Neck Surgery Department, University of Sao Paulo Medical School, Sao Paulo, Brazil
10Otorhinolaryngology—Head and Neck Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
11Research Programme in Systems Oncology, Faculty of Medicine, University of Helsinki, Helsinki, Finland
12Division of Ear, Nose and Throat Diseases, Department of Clinical Sciences, Intervention and Technology, Karolinska Institute and Karolinska University Hospital, Stockholm, Sweden
13Medical Informatics and Data Analysis Research Group, University of Oulu, Oulu, Finland
14Oral and Maxillofacial Diseases, University of Helsinki, Helsinki, Finland
15Cancer and Translational Medicine Research Unit, Medical Research Center Oulu, University of Oulu and Oulu University Hospital, Oulu, Finland
Format: article
Version: accepted version
Access: open
Online Access: PDF Full Text (PDF, 7.5 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe2020061042593
Language: English
Published: John Wiley & Sons, 2020
Publish Date: 2021-01-29
Description:

Abstract

Little is known about the histopathological characteristics that may differentiate early oral tongue cancer (OTSCC) between young and older patients. From a total of 311 cases diagnosed with clinically early‐stage OTSCC at 6 institutions, only 42 patients were young patients were aged ≤45 years. For comparison, 42 patients >60 years old were matched for center of management, clinical stage and gender. We compared epithelial and stromal histopathologic parameters between the two groups. Most of the parameters were similar between the two groups, although the young patients appeared to have marginally higher intensity of tumor budding, histologic risk score, infiltrative pattern of invasion and tumor‐stroma ratio. However, none of the factors showed significant difference when comparing the two groups. The histological parameters reflect mechanisms of invasive growth and tissue response to invasive growth, but not the etiological difference in OTSCC between young and older patients. Further investigations are necessary to compare the genetic background of early OTSCC in the two groups.

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Series: Oral diseases
ISSN: 1354-523X
ISSN-E: 1601-0825
ISSN-L: 1354-523X
Volume: 26
Issue: 5
Pages: 1081 - 1085
DOI: 10.1111/odi.13288
OADOI: https://oadoi.org/10.1111/odi.13288
Type of Publication: A1 Journal article – refereed
Field of Science: 3122 Cancers
Subjects:
early-stage
histopathological characteristics
matched-pair analysis
oral tongue cancer
young
Article
Funding: This work was supported by Sigrid Juselius Foundation and Finnish Cancer Society.
Copyright information: © 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. All rights reserved. This is the peer reviewed version of the following article: Bello, IO, Almangush, A, Heikkinen, I, et al. Histological characteristics of early‐stage oral tongue cancer in young versus older patients: A multicenter matched‐pair analysis. Oral Dis. 2020; 00: 1– 5, which has been published in final form at https://doi.org/10.1111/odi.13288. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving."