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Dourado, MR, Miwa, KYM, Hamada, GB, Paranaíba, LMR, Sawazaki‐Calone, Í, Domingueti, CB, Ervolino de Oliveira, C, Furlan, ECB, Longo, BC, Almangush, A, Salo, T & Coletta, RD. ( 2020) Prognostication for oral squamous cell carcinoma patients based on the tumour–stroma ratio and tumour budding. Histopathology 76, 906–918. https://doi.org/10.1111/his.14070

Prognostication for oral squamous cell carcinoma patients based on the tumour–stroma ratio and tumour budding

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Author: Dourado, Maurício R1; Miwa, Karen Y M1; Hamada, Guilherme B1;
Organizations: 1Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, São Paulo
2Department of Pathology and Parasitology, Inst itute of Biomedical Sciences, Federal Uni versity of Alfenas (UNIFAL-MG), Alfenas , Minas Gerais
3Oral Pathology and Ora l Medicine, Dentistry School, Western Paraná State University, Cascavel, Paraná
4Biomedicine, University José do Rosário Vellano (UNIFENAS), Varginha, Minas Ger ais, Brazil
5Department of Pathology, University of Helsinki, Helsinki
6Institute of Biomedicine, Pathology, University of Turku, Turku
7Cancer and Translational Medicine Research Unit, Faculty of Medicine and Medical Research Centre Oulu, Oulu University Hospital, University of Oulu, Oulu
8Institute of Oral and Maxillofaci al Disease, University of Helsinki
9Department of Pathology, Helsinki University Hospital, HUSLAB, Helsinki, Finland
Format: article
Version: accepted version
Access: open
Online Access: PDF Full Text (PDF, 45.8 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe2020061042616
Language: English
Published: John Wiley & Sons, 2020
Publish Date: 2021-01-27
Description:

Abstract

Aims: Previous studies have demonstrated that the tumour–stroma ratio (TSR) and tumour budding are of prognostic value for oral squamous cell carcinomas (OSCCs). The aim of this study was to evaluate the prognostic significance of those histological parameters, individually and in combination, for OSCC.

Methods and results: The TSR and tumour budding (the presence of five or more buds at the invasive front) were estimated in 254 patients with OSCC. The clinicopathological association was investigated with a chi‐square test, and the prognostic significance (cancer‐specific survival and disease‐free survival) was verified with Kaplan–Meier analysis and the Cox proportional hazard model. The TSR (≥50%, stroma‐rich) was significantly and independently associated with both shortened cancer‐specific survival and poor disease‐free survival, whereas tumour budding was significantly associated with reduced cancer‐specific survival. The TSR/tumour budding model was independently associated with a high risk of cancer mortality and recurrence (disease‐free survival). In patients with early‐stage tumours (clinical stage I and II, n = 103), the TSR, tumour budding and the TSR/tumour budding model were significantly associated with both cancer‐related death and recurrence, whereas, in advanced‐stage tumours (clinical stage III and IV, n = 144), only the TSR and the TSR/tumour budding model were significantly associated with cancer‐specific survival.

Conclusion: The TSR, tumour budding and their combination provide significant information on OSCC outcome, suggesting that their incorporation in the routine evaluation of histopathological specimens might be useful in prognostication for OSCC patients.

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Series: Histopathology
ISSN: 0309-0167
ISSN-E: 1365-2559
ISSN-L: 0309-0167
Volume: 76
Issue: 6
DOI: 10.1111/his.14070
OADOI: https://oadoi.org/10.1111/his.14070
Type of Publication: A1 Journal article – refereed
Field of Science: 3122 Cancers
Subjects:
oral cancer
prognosis
tumour budding
tumour–stroma ratio
Article
Funding: This work was supported by grants from Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) (2018/16077‐6 to R. D. Coletta). L. M. R. Paranaíba is supported by Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG) (APQ 00205.16). M. R. Dourado (2017/26764‐8), K. Y. M. Miwa (2018/16754‐8) and G. B. Hamada (2018/17689‐5) are research fellows supported by FAPESP.
Copyright information: © 2020 John Wiley & Sons Ltd. This is the peer reviewed version of the following article: Dourado, MR, Miwa, KYM, Hamada, GB, Paranaíba, LMR, Sawazaki‐Calone, Í, Domingueti, CB, Ervolino de Oliveira, C, Furlan, ECB, Longo, BC, Almangush, A, Salo, T & Coletta, RD. ( 2020) Prognostication for oral squamous cell carcinoma patients based on the tumour–stroma ratio and tumour budding. Histopathology 76, 906– 918, which has been published in final form at https://doi.org/10.1111/his.14070. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving