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Risk of second primary cancer in oral squamous cell carcinoma |
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| Author: | Mroueh, Rayan1; Nevala, Aapeli2; Haapaniemi, Aaro1; |
| Organizations: |
1Department of Otorhinolaryngology ‐ Head and Neck Surgery, University of Helsinki and HUS Helsinki University Hospital, Helsinki, Finland 2Finnish Cancer Registry, Helsinki, Finland 3Finnish Cancer Registry, Institute for Statistical and Epidemiological Cancer and Research, Helsinki, Finland
4Faculty of Social Sciences, University of Tampere, Tampere, Finland
5Department of Public Health, School of Medicine, University of Helsinki, Helsinki, Finland 6Cancer and Translational Medicine Unit, University of Oulu, Medical Research Unit, Oulu University Hospital, Helsinki, Finland 7Oral and Maxillofacial Diseases, University of Helsinki, Helsinki, Finland 8Haartman Institute, University of Helsinki, Helsinki, Finland 9Division of Ear, Nose and Throat Diseases, Department of Clinical Sciences, Intervention and Technology, Karolinska Institutet and Karolinska Hospital, Stockholm, Sweden 10Research Program in Systems Oncology, Faculty of Medicine, University of Helsinki, Helsinki, Finland |
| Format: | article |
| Version: | accepted version |
| Access: | open |
| Online Access: | PDF Full Text (PDF, 0.8 MB) |
| Persistent link: | http://urn.fi/urn:nbn:fi-fe2020061242927 |
| Language: | English |
| Published: |
John Wiley & Sons,
2020
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| Publish Date: | 2021-02-14 |
| Description: |
AbstractBackground: The incidence and survival of oral squamous cell carcinoma (OSCC) patients have increased in recent years. Understanding their long‐term survival aspects is essential for optimal treatment and follow‐up planning. Almost one in five cancers diagnosed occurs nowadays in individuals with a previous diagnosis of cancer. Methods: Patients diagnosed with primary OSCC during 1953‐2015 were retrieved from the Finnish Cancer Registry. Both standardized incidence ratios (SIR) and excess absolute risk (EAR) per 1000 person‐years at risk (PYR) of second primary cancer (SPC) were calculated relative to the general population. Results: Among 6602 first primary OSCC patients there were 640 (10%) SPCs. The SIR for SPCs was 1.85 (95% CI: 1.71‐1.99, P < .001) corresponding to an EAR of 8.78 (95% CI: 7.29‐10.26). Conclusions: Health care professionals should be aware of the second primary cancer risk after management of primary OSCC and patients need to be counseled about this phenomenon. see all
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| Series: |
Head & neck |
| ISSN: | 1043-3074 |
| ISSN-E: | 1097-0347 |
| ISSN-L: | 1043-3074 |
| Volume: | 42 |
| Issue: | 8 |
| Pages: | 1848 - 1858 |
| DOI: | 10.1002/hed.26107 |
| OADOI: | https://oadoi.org/10.1002/hed.26107 |
| Type of Publication: |
A1 Journal article – refereed |
| Field of Science: |
3122 Cancers |
| Subjects: | |
| Copyright information: |
© 2020 Wiley Periodicals, Inc. This is the peer reviewed version of the following article: Mroueh, R, Nevala, A, Haapaniemi, A, Pitkäniemi, J, Salo, T, Mäkitie, AA. Risk of second primary cancer in oral squamous cell carcinoma. Head & Neck. 2020; 42: 1848– 1858, which has been published in final form at https://doi.org/10.1002/hed.26107. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving."
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