University of Oulu

Ahola, S., Zhivonitko, V., Mankinen, O. et al. Ultrafast multidimensional Laplace NMR for a rapid and sensitive chemical analysis. Nat Commun 6, 8363 (2015). https://doi.org/10.1038/ncomms9363

Ultrafast multidimensional Laplace NMR for a rapid and sensitive chemical analysis

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Author: Ahola, Susanna1; Zhivonitko, Vladimir V2,3; Mankinen, Otto1;
Organizations: 1Faculty of Science, NMR Research Group, University of Oulu, PO Box 3000, 90014 Oulu, Finland
2Laboratory of Magnetic Resonance Microimaging, International Tomography Center SB RAS, Instututskaya Street 3A, 630090 Novosibirsk, Russia
3Department of Natural Sciences, Novosibirsk State University, Pirogova Street 2, 630090 Novosibirsk, Russia
4Department of Chemistry, Texas A&M University, 3255 TAMU, College Station, Texas 77843- 3255, USA
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, )
Persistent link: http://urn.fi/urn:nbn:fi-fe2020061844893
Language: English
Published: Springer Nature, 2015
Publish Date: 2020-06-18
Description:

Abstract

Traditional nuclear magnetic resonance (NMR) spectroscopy relies on the versatile chemical information conveyed by spectra. To complement conventional NMR, Laplace NMR explores diffusion and relaxation phenomena to reveal details on molecular motions. Under a broad concept of ultrafast multidimensional Laplace NMR, here we introduce an ultrafast diffusion-relaxation correlation experiment enhancing the resolution and information content of corresponding 1D experiments as well as reducing the experiment time by one to two orders of magnitude or more as compared with its conventional 2D counterpart. We demonstrate that the method allows one to distinguish identical molecules in different physical environments and provides chemical resolution missing in NMR spectra. Although the sensitivity of the new method is reduced due to spatial encoding, the single-scan approach enables one to use hyperpolarized substances to boost the sensitivity by several orders of magnitude, significantly enhancing the overall sensitivity of multidimensional Laplace NMR.

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Series: Nature communications
ISSN: 2041-1723
ISSN-E: 2041-1723
ISSN-L: 2041-1723
Volume: 6
Article number: 8363
DOI: 10.1038/ncomms9363
OADOI: https://oadoi.org/10.1038/ncomms9363
Type of Publication: A1 Journal article – refereed
Field of Science: 114 Physical sciences
Subjects:
Funding: The financial support by grants from the Academy of Finland (#279721, #289649 and #294027), the Emil Aaltonen foundation, the Council on Grants of the President of the Russian Federation (MK-1329.2014.3) and the Welch Foundation (Grant A-1658) is gratefully acknowledged.
Academy of Finland Grant Number: 279721
289649
294027
Detailed Information: 279721 (Academy of Finland Funding decision)
289649 (Academy of Finland Funding decision)
294027 (Academy of Finland Funding decision)
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