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L. Björnholm, J. Nikkinen, V. Kiviniemi, S. Niemelä, M. Drakesmith, J.C. Evans, G.B. Pike, L. Richer, Z. Pausova, J. Veijola, T. Paus, Prenatal exposure to maternal cigarette smoking and structural properties of the human corpus callosum, NeuroImage, Volume 209, 2020, 116477, ISSN 1053-8119, https://doi.org/10.1016/j.neuroimage.2019.116477

Prenatal exposure to maternal cigarette smoking and structural properties of the human corpus callosum

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Author: Björnholm, L.1; Nikkinen, J.2,3; Kiviniemi, V.4,5;
Organizations: 1Department of Psychiatry, Research Unit of Clinical Neuroscience, University of Oulu and Oulu University Hospital, Oulu, Finland
2Department of Radiotherapy, Oulu University Hospital, Oulu, Finland
3MIPT/MRC, University of Oulu and Oulu University Hospital, Oulu, Finland
4Institute of Diagnostics, Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland
5Oulu Functional Neuroimaging, MIPT/MRC, University of Oulu and Oulu University Hospital, Oulu, Finland
6Department of Psychiatry, University of Turku, Turku, Finland
7Addiction Psychiatry Unit, Department of Psychiatry, Hospital District of Southwest Finland, Finland
8School of Psychology, Cardiff University, Cardiff, United Kingdom
9Department of Radiology and Clinical Neurosciences, University of Calgary, Calgary, AB, Canada
10Department of Health Sciences, Université du Québec à Chicoutimi, Chicoutimi, QC, Canada
11The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada
12Departments of Physiology and Nutritional Sciences, University of Toronto, Toronto, ON, Canada
13Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, Toronto, Canada
14Departments of Psychology and Psychiatry, University of Toronto, Toronto, Canada
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 0.6 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe2020062245257
Language: English
Published: Elsevier, 2020
Publish Date: 2020-06-22
Description:

Abstract

Alterations induced by prenatal exposure to nicotine have been observed in experimental (rodent) studies. While numerous developmental outcomes have been associated with prenatal exposure to maternal cigarette smoking (PEMCS) in humans, the possible relation with brain structure is less clear. Here we sought to elucidate the relation between PEMCS and structural properties of human corpus callosum in adolescence and early adulthood in a total of 1,747 youth. We deployed three community-based cohorts of 446 (age 25–27 years, 46% exposed), 934 (age 12–18 years, 47% exposed) and 367 individuals (age 18–21 years, 9% exposed). A mega-analysis revealed lower mean diffusivity in the callosal segments of exposed males. We speculate that prenatal exposure to maternal cigarette smoking disrupts the early programming of callosal structure and increases the relative portion of small-diameter fibres.

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Series: Neuroimage
ISSN: 1053-8119
ISSN-E: 1095-9572
ISSN-L: 1053-8119
Volume: 209
Article number: 116477
DOI: 10.1016/j.neuroimage.2019.116477
OADOI: https://oadoi.org/10.1016/j.neuroimage.2019.116477
Type of Publication: A1 Journal article – refereed
Field of Science: 3112 Neurosciences
3126 Surgery, anesthesiology, intensive care, radiology
Subjects:
Article
Funding: ALSPAC: The UK Medical Research Council and the Wellcome Trust (Grant ref: 092,731) and the University of Bristol provide core support for ALSPAC. This paper was supported by grants from the National Institutes of Health (R01MH085772 to T. Paus). NFBC1986: The Northern Finland Birth Cohort 1986 is funded by University of Oulu, University Hospital of Oulu, Academy of Finland, Sigrid Juselius Foundation, European Commission (EURO-BLCS, Framework 5 award QLG1-CT-2000-01643), NIH/NIMH (5R01MH63706:02). This work has also been funded by Finnish Cultural Foundation (North Ostrobothnia Regional fund) and Jenny and Antti Wihuri Foundation. Funding was also received from the University of Oulu Graduate School, Research Foundation of Psychiatry, Juho Vainio Foundation, Yrjö Jahnsson Foundation, Päivikki and Sakari Sohlberg Foundation and the Instrumentarium Science Foundation.
Copyright information: © 2019 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
  https://creativecommons.org/licenses/by-nc-nd/4.0/