University of Oulu

Mankinen, O., Zhivonitko, V.V., Selent, A. et al. Ultrafast diffusion exchange nuclear magnetic resonance. Nat Commun 11, 3251 (2020).

Ultrafast diffusion exchange nuclear magnetic resonance

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Author: Mankinen, Otto1; Zhivonitko, Vladimir V.1; Selent, Anne1;
Organizations: 1NMR Research Unit, University of Oulu, P.O.Box 3000, FIN-90014 Oulu, Finland
2NANOMO Research Unit, University of Oulu, P.O. Box 3000, FIN-90014, Oulu, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 1.3 MB)
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Language: English
Published: Springer Nature, 2020
Publish Date: 2020-06-30


The exchange of molecules between different physical or chemical environments due to diffusion or chemical transformations has a crucial role in a plethora of fundamental processes such as breathing, protein folding, chemical reactions and catalysis. Here, we introduce a method for a single-scan, ultrafast NMR analysis of molecular exchange based on the diffusion coefficient contrast. The method shortens the experiment time by one to four orders of magnitude. Consequently, it opens the way for high sensitivity quantification of important transient physical and chemical exchange processes such as in cellular metabolism. As a proof of principle, we demonstrate that the method reveals the structure of aggregates formed by surfactants relevant to aerosol research.

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Series: Nature communications
ISSN: 2041-1723
ISSN-E: 2041-1723
ISSN-L: 2041-1723
Volume: 11
Article number: 3251
DOI: 10.1038/s41467-020-17079-7
Type of Publication: A1 Journal article – refereed
Field of Science: 114 Physical sciences
116 Chemical sciences
Funding: The authors gratefully acknowledge funding from the European Research Council under Horizon 2020, projects Ultrafast Laplace NMR (grant agreement no. 772110) and SURFACE (grant agreement no. 717022), Academy of Finland (grant nos. 289649, 294027, 308238, 314175, 319216, 321701 and 323480), KAUTE foundation, Finnish Cultural Foundation–Fanny and Yrjö Similä fund, Tauno Tönning Foundation, Orion research foundation, Fortum Foundation and The University of Oulu Scholarship Foundation–Science Fund. The financial support from the Kvantum institute (University of Oulu) is also acknowledged.
EU Grant Number: (772110) UFLNMR - Ultrafast Laplace NMR
(717022) SURFACE - The unexplored world of aerosol surfaces and their impacts.
Academy of Finland Grant Number: 289649
Detailed Information: 289649 (Academy of Finland Funding decision)
294027 (Academy of Finland Funding decision)
308238 (Academy of Finland Funding decision)
314175 (Academy of Finland Funding decision)
319216 (Academy of Finland Funding decision)
321701 (Academy of Finland Funding decision)
323480 (Academy of Finland Funding decision)
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