University of Oulu

Korhonen, K., Unkila-Kallio, L., Alfthan, H. et al. Plasma pentraxin 3 is higher in early ovarian hyperstimulation syndrome than in uncomplicated in vitro fertilization cycle of high-risk women. Arch Gynecol Obstet 301, 1569–1578 (2020).

Plasma pentraxin 3 is higher in early ovarian hyperstimulation syndrome than in uncomplicated in vitro fertilization cycle of high-risk women

Saved in:
Author: Korhonen, Kati1; Unkila-Kallio, Leila1; Alfthan, Henrik2;
Organizations: 1Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Haartmaninkatu 2, PO Box 140, 00290, Helsinki, Finland
2HUSLAB, Helsinki University Hospital, Topeliuksenkatu 32, 00290, Helsinki, Finland
3Clinical Chemistry, University of Helsinki and Helsinki University Hospital, Haartmaninkatu 8, 00290, Helsinki, Finland
4Folkhälsan Research Center, Biomedicum Helsinki, Haartmaninkatu 8, 00290, Helsinki, Finland
5PEDEGO Research Unit, Medical Research Center, Obstetrics and Gynecology, University of Oulu and Oulu University Hospital, Pentti Kaiteran katu 1, Linnanmaa, 90014, Oulu, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 0.8 MB)
Persistent link:
Language: English
Published: Springer Nature, 2020
Publish Date: 2020-07-02


Purpose: Pentraxin 3 (PTX3) is a locally secreted, quicker responsive pro-inflammatory protein than C-reactive protein (CRP). We evaluated the value of PTX3 in the prediction of ovarian hyperstimulation syndrome (OHSS), a severe complication of in vitro fertilization (IVF).

Methods: This two-year prospective follow-up study included 27 women with uncomplicated IVF-cycles (IVF group) and 31 patients diagnosed with moderate or severe early OHSS (OHSS group). PTX3 was analysed from follicular fluid (FF) and serial blood samples with enzyme-linked immunoassay and CRP with particle-enhanced immunoturbidimetric assay. The value of PTX3 and CRP in detecting OHSS was examined with receiver operating characteristic (ROC) curve analysis and expressed as the area under the curve (AUC).

Results: The circulating PTX3 level peaked at two days after oocyte pick-up (OPU2), and in the OHSS group the level was 1.9 times higher (P = 0.006) than in the IVF group. However, in ROC curve analysis PTX3 (AUC 0.79, best cut off 1.1 µg/L) was not superior to CRP (AUC 0.87; best cut off 9.5 mg/L) in predicting early OHSS. In the IVF group, the FF-PTX3 concentration was 15–20 times higher than in the plasma. PTX3 level at OPU2 correlated with the number of punctured follicles (r = 0.56, n = 22, P = 0.006). Triggering with human chorionic gonadotrophin or early pregnancy had no effect on PTX3 level.

Conclusion: The elevated PTX3 concentration in OHSS at OPU2, when freeze-all embryos strategy is still possible to consider, indicates that PTX3 level could provide additional benefit in the risk assessment for early OHSS.

see all

Series: Archives of gynecology and obstetrics
ISSN: 0932-0067
ISSN-E: 1432-0711
ISSN-L: 0932-0067
Volume: 301
Issue: 6
Pages: 1569 - 1578
DOI: 10.1007/s00404-020-05556-9
Type of Publication: A1 Journal article – refereed
Field of Science: 3123 Gynaecology and paediatrics
Funding: Open access funding provided by University of Helsinki including Helsinki University Central Hospital. We thank Ms. Teija Karkkulainen and Mrs. Kirsti Räsänen for organizing the data and laboratory samples, and Mrs. Kirsti Räsänen for PTX3 measurements. MD Antti Haarahiltunen is thanked for the primary evaluation of the data. Study funding was by the State Funding for University Level Research, Serono research grant, The Jane and Aatos Erkko Foundation, Sigrid Juselius Foundation, Orion Research Foundation, Academy of Finland and The Finnish Medical Foundation. Financiers had no role in the study protocol or the interpretation of the data.
Copyright information: © The Author(s) 2020. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit