Valtonen, RIP, Ikäheimo, TM, Hintsala, HE, et al. Endothelial function in response to exercise in the cold in patients with coronary artery disease. Clin Physiol Funct Imaging. 2020; 40: 245– 256. https://doi.org/10.1111/cpf.12631
Endothelial function in response to exercise in the cold in patients with coronary artery disease
|Author:||Valtonen, Rasmus I. P.1,2; Ikäheimo, Tiina M.1,2; Hintsala, Heidi E.1,2,3;|
1Center for Environmental and Respiratory Health Research (CERH), University of Oulu, Oulu, Finland
2Medical Research Center, University of Oulu and Oulu University Hospital, Oulu, Finland
3Centria University of Applied Sciences, Kokkola, Finland
4Cardiovascular Research Group, Division of Cardiology, Oulu University Hospital, University of Oulu, Oulu, Finland
5Research Unit of Internal Medicine, Medical Research Center Oulu, University of Oulu and Oulu University Hospital, Oulu, Finland
6Department of Internal Medicine, University of Texas Southwestern Medical Center and the Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital, Dallas, TX, USA
7Aeromedical Centre, Finnish Defence Forces, Helsinki, Finland
|Online Access:||PDF Full Text (PDF, 1 MB)|
|Persistent link:|| http://urn.fi/urn:nbn:fi-fe2020070246750
John Wiley & Sons,
|Publish Date:|| 2020-07-02
Background: Regular long‐term physical exercise has favourable effects on endothelial function in patients with coronary artery disease (CAD). However, the effects of an acute exercise bout in the cold on endothelial function are not known.
Methods: At first, the effects of moderate‐intensity aerobic lower‐body exercise were assessed in CAD patients (n = 16) in a neutral [+22°C] and cold [−15°C] environment. Secondly, responses to static and dynamic upper‐body exercise in a neutral [+22°C] and cold [−15°C] environment were investigated in CAD patients (n = 15). All experiments were performed in a random order. Endothelial function was measured by flow‐mediated dilation (FMD) of the brachial artery in response to reactive hyperaemia, before and after the exposures in a neutral environment.
Results: No significant temperature*exercise*condition (pre–post) interaction was observed in FMD% when comparing rest versus aerobic exercise or static versus dynamic upper‐body exercise. Relative reactive hyperaemia during FMD protocol, measured by changes in shear rate, was elevated after rest compared to aerobic exercise (p = 0.001) and after static compared to dynamic upper‐body exercise (p < 0.001). However, no significant temperature*exercise*condition interaction was observed when FMD% was normalized for shear rate.
Conclusions: Endothelial function to an acute bout of exercise among CAD patients was not modified by the environmental temperature where the exercise was performed. The present findings argue against the hypothesis that exercise in cold environmental conditions impairs endothelial function in patients with CAD.
Clinical physiology and functional imaging
|Pages:||245 - 256|
|Type of Publication:||
A1 Journal article – refereed
|Field of Science:||
3121 General medicine, internal medicine and other clinical medicine
The study was funded through grants from the Finnish Ministry of Education and Culture (TI), Yrjö Jahnsson Foundation (TI), Juho Vainio Foundation (RV), Paulo Foundation (AK) and Finnish Foundation for Cardiovascular Research (AK).
© 2020 The Authors. Clinical Physiology and Functional Imaging published by John Wiley & Sons Ltd on behalf of Scandinavian Society of Clinical Physiology and Nuclear Medicine This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.