University of Oulu

Korpela, N., Kaikkonen, K., Auvinen, J., Tulppo, M. P., Junttila, J., Perkiömäki, J., … Kiviniemi, A. M. (2020). Early Growth Patterns and Cardiac Structure and Function at Midlife: Northern Finland 1966 Birth Cohort Study. The Journal of Pediatrics, 221, 151–158.e1.

Early growth patterns and cardiac structure and function at midlife : Northern Finland 1966 Birth Cohort study

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Author: Korpela, Nelli1; Kaikkonen, Kari1; Auvinen, Juha2,3;
Organizations: 1Research Unit of Internal Medicine, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland
2Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland
3Unit of Primary Health Care, Medical Research Center Oulu, Oulu University Hospital, Oulu, Finland
4Biocenter Oulu, University of Oulu, Oulu, Finland
5Department of Epidemiology and Biostatistics, MRC–PHE Centre for Environment & Health, School of Public Health, Imperial College London, London, UK
6Department of Life Sciences, College of Health and Life Sciences, Brunel University London, UK
Format: article
Version: accepted version
Access: open
Online Access: PDF Full Text (PDF, 0.5 MB)
Persistent link:
Language: English
Published: Elsevier, 2020
Publish Date: 2021-05-20


Objectives: To evaluate the influence of early growth patterns that have previously been associated with later cardiometabolic risk on cardiac left ventricular (LV) structure and function in midlife.

Study design: A subpopulation of the Northern Finland Birth Cohort 1966 took part in follow-up, including echocardiography (n = 1155) at the age of 46 years. Body mass index (BMI) growth curves were modeled based on frequent anthropometric measurements in childhood. Age and BMI at adiposity peak (n = 482, mean age 9.0 months) and at adiposity rebound (n = 586, mean age 5.8 years) were determined. Results are reported as unstandardized beta (β) or OR with 95% CIs for 1 SD increase in early growth variable.

Results: Earlier adiposity rebound was associated with increased LV mass index (β = −4.10 g/m² (−6.9, −1.3); P = 0.004) and LV end-diastolic volume index (β = −2.36 mL/m² (−3.9, −0.84); P = 0.002) as well as with eccentric LV hypertrophy (OR 0.54 [0.38, 0.77]; P = 0.001) in adulthood in males. BMI at adiposity rebound was directly associated with LV mass index (β = 2.33 g/m² [0.80, 3.9]; P = 0.003). Higher BMI at both adiposity peak and at adiposity rebound were associated with greater LV end-diastolic volume index (β = 1.47 mL/m²; [0.51, 2.4], β = 1.28 mL/m² [0.41, 2.2], respectively) and also with eccentric LV hypertrophy (OR 1.41 [1.10, 1.82], OR 1.53 [1.23, 1.91], respectively) and LV concentric remodeling (OR 1.38 [1.02, 1.87], OR 1.40 [1.06, 1.83], respectively) in adulthood (P < 0.05 for all). These relationships were only partly mediated by adult BMI.

Conclusions: Early growth patterns in infancy and childhood contribute to cardiac structure at midlife.

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Series: Journal of pediatrics
ISSN: 0022-3476
ISSN-E: 1097-6833
ISSN-L: 0022-3476
Volume: 221
Pages: 151 - 158.e1
DOI: 10.1016/j.jpeds.2020.03.007
Type of Publication: A1 Journal article – refereed
Field of Science: 3142 Public health care science, environmental and occupational health
3121 General medicine, internal medicine and other clinical medicine
Funding: Supported by the Academy of Finland (no. 285547), Finnish Foundation for Cardiovascular Research, European Union's Horizon 2020 research and innovation program (633595, EU H2020-PHC-2014 633595, DynaHEALTH, EU H2020-SC1-2016-2017, LIFECYCLE, EU H2020-HCO-2014, iHEALTH), Yrjö Jahnsson Foundation, Aarne Koskelo Foundation, and Oulu University Scholarship Foundation. NFBC1966 received financial support from University of Oulu (no. 24000692), Oulu University Hospital (no. 24301140), and ERDF European Regional Development Fund (no. 539/2010 A31592). Sponsors had no role in study design, the collection, analysis or interpretation of the data, writing of the report or the decision to submit the manuscript for publication. The authors declare no conflicts of interest.
EU Grant Number: (633595) DYNAHEALTH - Understanding the dynamic determinants of glucose homeostasis and social capability to promote Healthy and active aging
(643774) iHealth-T2D - Family-based intervention to improve healthy lifestyle and prevent Type 2 Diabetes amongst South Asians with central obesity and prediabetes
(733206) LIFECYCLE - Early-life stressors and LifeCycle health
Academy of Finland Grant Number: 285547
Detailed Information: 285547 (Academy of Finland Funding decision)
Copyright information: © 2020. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http:/