University of Oulu

Karthikeyan, P.; Moradi, S.; Ferdinando, H.; Zhao, Z.; Myllylä, T. Optics Based Label-Free Techniques and Applications in Brain Monitoring. Appl. Sci. 2020, 10, 2196.

Optics based label-free techniques and applications in brain monitoring

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Author: Karthikeyan, Priya1; Moradi, Sadegh2; Ferdinando, Hany1;
Organizations: 1Research Unit of Medical Imaging, Physics and Technology, Faculty of Medicine, University of Oulu, 90220 Oulu, Finland
2Optoelectronics and Measurement Techniques Research Unit, Faculty of Information Technology and Electrical Engineering, University of Oulu, 90570 Oulu, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 1.7 MB)
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Language: English
Published: Multidisciplinary Digital Publishing Institute, 2020
Publish Date: 2020-07-07


Functional near-infrared spectroscopy (fNIRS) has been utilized already around three decades for monitoring the brain, in particular, oxygenation changes in the cerebral cortex. In addition, other optical techniques are currently developed for in vivo imaging and in the near future can be potentially used more in human brain research. This paper reviews the most common label-free optical technologies exploited in brain monitoring and their current and potential clinical applications. Label-free tissue monitoring techniques do not require the addition of dyes or molecular contrast agents. The following optical techniques are considered: fNIRS, diffuse correlations spectroscopy (DCS), photoacoustic imaging (PAI) and optical coherence tomography (OCT). Furthermore, wearable optical brain monitoring with the most common applications is discussed.

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Series: Applied sciences
ISSN: 2076-3417
ISSN-E: 2076-3417
ISSN-L: 2076-3417
Volume: 10
Issue: 6
Article number: 2196
DOI: 10.3390/app10062196
Type of Publication: A1 Journal article – refereed
Field of Science: 217 Medical engineering
3112 Neurosciences
Funding: The work was supported by the Academy of Finland (grants 314502 and 318347) and Suomen Aivosäätiö.
Academy of Finland Grant Number: 314502
Detailed Information: 314502 (Academy of Finland Funding decision)
318347 (Academy of Finland Funding decision)
Copyright information: © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (