University of Oulu

Vinciguerra, F.; Graziano, M.; Hagnäs, M.; Frittitta, L.; Tumminia, A. Influence of the Mediterranean and Ketogenic Diets on Cognitive Status and Decline: A Narrative Review. Nutrients 2020, 12, 1019.

Influence of the Mediterranean and Ketogenic Diets on cognitive status and decline : a narrative review

Saved in:
Author: Vinciguerra, Federica1; Graziano, Marco1; Hagnäs, Maria1,2,3;
Organizations: 1Endocrinology, Department of Clinical and Experimental Medicine, University of Catania, Garibaldi Medical Center, Via Palermo 636, 95122 Catania, Italy
2Center for Life Course Health Research, University of Oulu, Aapistie 5/PO Box 5000, 90014 Oulu, Finland
3Rovaniemi Health Center, Koskikatu 25, 96200 Rovaniemi, Finland
4Diabetes, Obesity and Dietetic Center, Garibaldi Medical Center, Via Palermo 636, 95122 Catania, Italy
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 0.7 MB)
Persistent link:
Language: English
Published: Multidisciplinary Digital Publishing Institute, 2020
Publish Date: 2020-07-08


Alzheimer’s disease (AD) is the most common form of senile dementia, accounting for up to 70% of dementia cases. AD is a slowly progressive disease, which causes global mental deterioration by affecting various cognitive areas. A growing body of evidence has demonstrated that lifestyle habits and nutritional patterns could delay the natural course of the neurodegeneration process. There is no single dietary pattern unequivocally proven to prevent AD. Nevertheless, epidemiological data suggest that by adopting several dietary habits, especially if accompanied with a healthy lifestyle, the negative consequences of AD could potentially be delayed. Alongside with others, two specific eating patterns have been well investigated concerning their potential beneficial effect on cognitive status: the Mediterranean diet (MedDi) and the Ketogenic Diet (KD). Despite the different underlying mechanisms, both of them have demonstrated a fairly profitable role in reducing or delaying cognitive impairment. The aim of the present narrative review is to overview the existing research on the efficacy of MedDi and KD against AD-related cognitive decline, focusing on the proposed protective mechanisms of action. Although the current knowledge on this complex topic does not allow us, at this point, to make exhaustive conclusions, this information could be of help in order to better characterize the possible role of MedDi and KD as nonpharmacological therapies in the treatment of AD and, more generically, of neurodegenerative disorders.

see all

Series: Nutrients
ISSN: 2072-6643
ISSN-E: 2072-6643
ISSN-L: 2072-6643
Volume: 12
Issue: 4
Article number: 1019
DOI: 10.3390/nu12041019
Type of Publication: A2 Review article in a scientific journal
Field of Science: 3141 Health care science
Copyright information: © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (