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No detection of TSH or TSHR in oral lichen planus lesions in patients with or without hypothyroidism |
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| Author: | Vehviläinen, Mari1; Salem, Abdelhakim2; Asghar, Muhammad Yasir3; |
| Organizations: |
1Unit for Specialized Oral Care in the Metropolitan Area and Kirkkonummi, Department of Social Services and Health Care, City of Helsinki, Helsinki, Finland 2Translational Immunology Program (TRIMM), Department of Oral and Maxillofacial Diseases, Clinicum, University of Helsinki, Helsinki, Finland 3Cellular Physiology, Minerva Foundation Institute for Medical Research, Helsinki, Finland
4Cancer and Translational Medicine Research Unit, Faculty of Medicine, University of Oulu and Oulu University Hospital, Oulu, Finland
5Medical Research Center, Oulu University Hospital, Oulu, Finland 6Department of Oral and Maxillofacial Diseases, and Translational Immunology Program (TRIMM), University of Helsinki, Helsinki, Finland 7Institute of Dentistry, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland 8Oral Health Teaching Clinic and Oral and Maxillofacial Diseases Clinic, Kuopio University Hospital, Kuopio, Finland |
| Format: | article |
| Version: | accepted version |
| Access: | open |
| Online Access: | PDF Full Text (PDF, 2.6 MB) |
| Persistent link: | http://urn.fi/urn:nbn:fi-fe2020071047231 |
| Language: | English |
| Published: |
Informa,
2020
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| Publish Date: | 2021-02-07 |
| Description: |
AbstractObjective: An association between hypothyroidism (HT) and oral lichen planus (OLP) has been reported. However, the mechanisms that could explain this association remain unresolved. This study aimed to evaluate the expression of thyroid-stimulating hormone (TSH) and thyroid-stimulating hormone receptor (TSHR) in healthy oral mucosa and in OLP lesions of individuals with and without HT. Material and methods:: Immunohistochemical expression of TSH and TSHR was studied in oral mucosal biopsies obtained from 14 OLP patients with HT, 14 OLP patients without HT and 10 healthy controls without oral mucosal lesions. Gene expression of TSHR was investigated by using three different PCR techniques in oral mucosal samples from 7 OLP patients with HT, 3 OLP patients without HT, 9 healthy controls and in cultured human oral epithelial cells. Gene expression of TSH was examined by employing 2 PCR techniques in oral mucosal samples from 2 OLP patients with HT, 2 OLP patients without HT and 4 healthy controls. Results: TSH and TSHR stainings were negative in the studied oral mucosal specimens. Gene quantification assays demonstrated negative gene expression of TSH and TSHR in clinical and in vitro samples. Conclusions: These results suggest that TSH and TSHR may not be commonly involved in the pathogenetic mechanism that could explain the association between OLP and hypothyroidism. see all
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| Series: |
Acta odontologica Scandinavica |
| ISSN: | 0001-6357 |
| ISSN-E: | 1502-3850 |
| ISSN-L: | 0001-6357 |
| Volume: | 78 |
| Issue: | 5 |
| Pages: | 337 - 344 |
| DOI: | 10.1080/00016357.2020.1720798 |
| OADOI: | https://oadoi.org/10.1080/00016357.2020.1720798 |
| Type of Publication: |
A1 Journal article – refereed |
| Field of Science: |
3122 Cancers |
| Subjects: | |
| Funding: |
We would like to acknowledge the funders of this study: Orion Research Foundation; Emil Aaltonen Foundation; Finnish Dental Society Apollonia; and the Cancer Society of Finland. |
| Copyright information: |
© 2020 Acta Odontologica Scandinavica Society. This is an Accepted Manuscript of an article published by Taylor & Francis in Acta Odontologica Scandinavica on 7 Feb 2020, available online: https://doi.org/10.1080/00016357.2020.1720798. |