University of Oulu

M. Borovkova, A. Bykov, A. Popov, A. Pierangelo, T. Novikova, J. Pahnke, and I. Meglinski, "Evaluating β-amyloidosis progression in Alzheimer’s disease with Mueller polarimetry," Biomed. Opt. Express 11, 4509-4519 (2020).

Evaluating β-amyloidosis progression in Alzheimer’s disease with Mueller polarimetry

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Author: Borovkova, Mariia1; Bykov, Alexander1; Popov, Alexey2;
Organizations: 1Optoelectronics and Measurement Techniques, University of Oulu, 90570 Oulu, Finland
2VTT Technical Research Centre of Finland, 90590 Oulu, Finland
3LPICM, Ecole polytechnique, CNRS, Institut Polytechnique de Paris, 91764 Palaiseau, France
4Department of Neuro-/Pathology, University of Oslo & Oslo University Hospital, 0450 Oslo, Norway
5LIED, University of Lübeck, 23562 Lübeck, Germany
6Department of Pharmacology, Medical Faculty, University of Latvia, Riga 1586, Latvia
7Laboratory of Biophotonics, National Research Tomsk State University, Tomsk, Russia
8Institute of Engineering Physics for Biomedicine, National Research Nuclear University (MEPhI), Moscow 115409, Russia
9Department of Histology, Cytology and Embryology, Institute of Clinical Medicine N.V. Sklifosovsky, I.M. Sechenov First Moscow State Medical University, Moscow 119146, Russia
10College of Engineering and Physical Sciences, Aston University, Birmingham B4 7ET, United Kingdom
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 1.8 MB)
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Language: English
Published: Optical Society of America, 2020
Publish Date: 2020-08-11


We applied the wide-field Mueller imaging polarimetry for the screening of formalin-fixed paraffin-embedded samples of mouse brain tissue at different stages of brain β-amyloidosis in Alzheimer’s disease (AD). The accumulation of amyloid-beta (Aβ) deposits throughout the brain tissue is one of the key pathological hallmarks observed with the AD progression. We demonstrate that the presence of Aβ plaques influences the properties of backscattered polarized light, in particular, its degree of depolarization. By means of statistical analysis, we demonstrate that the high-order statistical moments of depolarization distributions, acquired with the multi-spectral Mueller imaging polarimetry, can be used as sensitive markers of the growing presence of Aβ plaques. The introduced label-free polarimetric approach has a potential to facilitate the current practice of the histopathology screening in terms of diagnosis accuracy, time and cost efficiency.

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Series: Biomedical optics express
ISSN: 2156-7085
ISSN-E: 2156-7085
ISSN-L: 2156-7085
Volume: 11
Issue: 8
Pages: 4509 - 4519
Article number: 4509
DOI: 10.1364/BOE.396294
Type of Publication: A1 Journal article – refereed
Field of Science: 114 Physical sciences
Funding: Horizon 2020 Framework Programme (Marie Skłodowska-Curie grant No.713606, 643417); Cost Actions (CA16118); the ATTRACT project funded by the EC under Grant Agreement (777222); Academy of Finland (314369, 325097, 326204); INFOTECH strategic funding; Deutsche Forschungsgemeinschaft (DFG PA930/12); Latvian Council of Science FLPP (lzp-2018/1-0275); Nasjonalforeningen for Folkehelsen (16154); HelseSØ (2016062, 2019054, 2019055); Norges Forskningsråd (251290 FRIMED2, 260786 PROP-AD); MEPhI Academic Excellence Project (02.a03.21.0005); Russian Science Foundation (19-72-30012); Tomsk State University (D.I. Mendeleev Fund Program).
EU Grant Number: (713606) I4FUTURE - Novel Imaging and Characterisation Methods in Bio, Medical, and Environmental Research and Technology Innovations
Academy of Finland Grant Number: 314369
Detailed Information: 314369 (Academy of Finland Funding decision)
325097 (Academy of Finland Funding decision)
326204 (Academy of Finland Funding decision)
Copyright information: © 2020 Optical Society of America under the terms of the OSA Open Access Publishing Agreement. Users may use, reuse, and build upon the article, or use the article for text or data mining, so long as such uses are for non-commercial purposes and appropriate attribution is maintained. All other rights are reserved.