Halonen, JI, Merikukka, M, Gissler, M, et al. Pathways from parental mental disorders to offspring's work disability due to depressive or anxiety disorders in early adulthood—The 1987 Finnish Birth Cohort. Depress Anxiety. 2019; 36: 305– 312. https://doi.org/10.1002/da.22847
Pathways from parental mental disorders to offspring‘s work disability due to depressive or anxiety disorders in early adulthood : the 1987 Finnish Birth Cohort
|Author:||Halonen, Jaana I.1; Merikukka, Marko2,3; Gissler, Mika4,5,6;|
1Finnish Institute of Occupational Health, Helsinki, Finland
2Department of Welfare, National Institute for Health and Welfare (THL), Oulu, Finland
3PEDEGO Research Unit, University of Oulu, Oulu, Finland
4Information Services Department, National Institute for Health and Welfare (THL), Helsinki, Finland
5Research Centre for Child Psychiatry, University of Turku, Turku, Finland
6Department of Neurobiology, Care Sciences and Society, Division of Family Medicine, Karolinska Institute, Stockholm, Sweden
7Department of Public Health and Caring Sciences, University of Uppsala, Uppsala, Sweden
8Social and Public Policy, Department of Social Research, University of Helsinki, Helsinki, Finland
9Department of Public Health, University of Helsinki, Helsinki, Finland
|Online Access:||PDF Full Text (PDF, 0.6 MB)|
|Persistent link:|| http://urn.fi/urn:nbn:fi-fe2020081249527
John Wiley & Sons,
|Publish Date:|| 2019-10-17
Background/Objectives: Parental mental disorders have been shown to predict offspring‘s mental health problems. We examined whether pathways from parental mental disorders to offspring‘s psychiatric work disability in early adulthood are mediated through offspring‘s mental disorders and social disadvantage in adolescence.
Methods: Study population consisted of the 1987 Finnish Birth Cohort. Data on parents‘ psychiatric care or work disability due to mental diagnosis between 1987 and 2000 and the cohort participants‘ health and social factors between 2001 and 2005 were derived from administrative national registers. From 2006 through 2015, 52,182 cohort participants were followed for admittance of psychiatric work disability due to depressive or anxiety disorders. First, we applied a pathway analysis to examine the occurrence of each path. We then used mediation analysis to assess the proportion of association between parental mental disorders and work disability mediated by offspring‘s health and social disadvantage.
Results: The pathway model indicated that the association from parental mental disorders to offspring‘s work disability due to depressive or anxiety disorder is through mental disorders and social disadvantage in adolescence. Odds Ratio for the total effect of parental mental disorders on offspring‘s psychiatric work disability was 1.85 (95% confidence interval [CI] 1.46–2.34) in the model including offspring‘s mental disorders that mediated this association by 35%. Corresponding results were 1.86 (95% CI 1.47–2.35) and 28% for social disadvantage in adolescence.
Conclusions: These findings suggest that intergenerational determination of work disability due to mental disorders could be addressed by actions supporting mental health and social circumstances in adolescence.
Depression & anxiety
|Pages:||305 - 312|
|Type of Publication:||
A1 Journal article – refereed
|Field of Science:||
3124 Neurology and psychiatry
The research was funded by the Finnish Academy (grant numbers 287488, 294096, and 319200 for T.L. and J.I.H.). M.M. received support from the Alli Paasikivi Foundation (2016), the Emil Aaltonen Foundation (2016), and the National Institute for Health and Welfare.
© 2018 Wiley Periodicals, Inc.. This is the peer reviewed version of the following article: Halonen, JI, Merikukka, M, Gissler, M, et al. Pathways from parental mental disorders to offspring's work disability due to depressive or anxiety disorders in early adulthood—The 1987 Finnish Birth Cohort. Depress Anxiety. 2019; 36: 305– 312, which has been published in final form at https://doi.org/10.1002/da.22847. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.