Kaseva, N., Vääräsmäki, M., Matinolli, H. et al. Maternal pre-pregnancy overweight and gestational diabetes and dietary intakes among young adult offspring. Nutr. Diabetes 10, 26 (2020). https://doi.org/10.1038/s41387-020-00129-w
Maternal pre-pregnancy overweight and gestational diabetes and dietary intakes among young adult offspring
|Author:||Kaseva, Nina1; Vääräsmäki, Marja1,2; Matinolli, Hanna-Maria1,3,4;|
1National Institute for Health and Welfare, Helsinki, Oulu, Finland
2PEDEGO Research Unit (Research Unit for Pediatrics, Dermatology, Clinical Genetics, Obstetrics and Gynecology), Medical Research Center Oulu (MRC Oulu), Oulu University Hospital and University of Oulu, Oulu, Finland
3Research Center for Child Psychiatry, University of Turku, Turku, Finland
4INVEST Research Flagship, University of Turku, Turku, Finland
5Department of Public Health, University of Helsinki, Helsinki, Finland
6Department of Psychology and Logopedics, University of Helsinki, Helsinki, Finland
7Children’s Hospital, Pediatric Research Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
8Department of Psychology, University of Warwick, Warwick, UK
9Department of Epidemiology and Biostatistics, MRC–PHE Centre for Environment & Health, School of Public Health, Imperial College London, London, UK
10Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland
11Biocenter Oulu, University of Oulu, Oulu, Finland
12Unit of Primary Care, Oulu University Hospital, Oulu, Finland
13Department of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
14Folkhälsan Research Center, Helsinki, Finland
15Department of Obstetrics and Gynecology, National University Singapore, Yong Loo Lin School of Medicine, Singapore, Singapore
16Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore
17Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway
|Online Access:||PDF Full Text (PDF, 0.5 MB)|
|Persistent link:|| http://urn.fi/urn:nbn:fi-fe2020081460547
|Publish Date:|| 2020-08-14
Background/Objectives: Maternal pre-pregnancy overweight/obesity and gestational diabetes (GDM) are associated with increased fat deposition in adult offspring. The purpose of this study was to identify if maternal pre-pregnancy overweight (body mass index (BMI) ≥ 25 kg/m²) or GDM are associated with dietary quality or intake in adult offspring.
Subjects/Methods: Participants (n = 882) from two longitudinal cohort studies (ESTER Maternal Pregnancy Disorders Study and the Arvo Ylppö Longitudinal Study) completed a validated food-frequency questionnaire at a mean age of 24.2 years (SD 1.3). Diet quality was evaluated by a Recommended Finnish Diet Index (RDI). The study sample included offspring of normoglycaemic mothers with pre-pregnancy overweight/obesity (ONO = 155), offspring of mothers with GDM regardless of BMI (OGDM = 190) and offspring of mothers with normal weight and no GDM (controls; n = 537).
Results: Among men, daily energy and macronutrient intakes were similar in ONO and controls. However, after adjusting for current offspring characteristics, including BMI, daily carbohydrate intake relative to total energy intake was higher in ONO-men [2.2 percentages of total energy intake (95% confidence interval 0.4, 4.0)]. In ONO-women, macronutrient intakes relative to total energy intake were similar with controls, while total daily energy intake seemed lower [−587.2 kJ/day (−1192.0, 4.4)]. After adjusting for confounders, this difference was attenuated. Adherence to a healthy diet, as measured by RDI, was similar in ONO and controls [mean difference: men 0.40 (−0.38, 1.18); women 0.25 (−0.50, 1.00)]. In OGDM vs. controls, total energy and macronutrient intakes were similar for both men and women. Also adherence to a healthy diet was similar [RDI: men 0.09 (−0.62, 0.80); women −0.17 (−0.93, 0.59)].
Conclusions: Our study suggested higher daily carbohydrate intake in male offspring exposed to maternal pre-pregnancy overweight/obesity, compared with controls. Prenatal exposure to GDM was not associated with adult offspring dietary intakes.
Nutrition & diabetes
|Type of Publication:||
A1 Journal article – refereed
|Field of Science:||
3123 Gynaecology and paediatrics
3121 General medicine, internal medicine and other clinical medicine
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