University of Oulu

Korpela, K, Renko, M, Vänni, P, et al. Microbiome of the first stool and overweight at age 3 years: A prospective cohort study. Pediatric Obesity. 2020; 15:e12680. https://doi.org/10.1111/ijpo.12680

Microbiome of the first stool and overweight at age 3 years : a prospective cohort study

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Author: Korpela, Katja1; Renko, Marjo1,2; Vänni, Petri1,3;
Organizations: 1PEDEGO Research Unit, Medical Research Center, University of Oulu, Oulu, Finland
2Department of Paediatrics, University of Eastern Finland, Kuopio, Finland
3Genobiomics Ltd, Oulu, Finland
4Department of Paediatrics and Adolescent Medicine, Oulu University Hospital, Oulu, Finland
5Genetics and Physiology, Faculty of Science, University of Oulu, Oulu, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 1 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe2020090165975
Language: English
Published: John Wiley & Sons, 2020
Publish Date: 2020-09-01
Description:

Abstract

Background: Several reports have revealed that the first‐pass meconium hosts a diverse microbiome, but its clinical significance is not known.

Objective: We designed a prospective population‐based cohort study to evaluate whether the meconium microbiome predicts subsequent growth in children.

Methods: The study comprised 212 consecutive newborns with a meconium sample and a follow‐up sample at 1 year of age. Trained nurses measured the children for weight and length using standardized techniques. We used next‐generation sequencing of bacterial 16S rRNA gene and machine‐learning approach for the analysis.

Results: The children with overweight at 3 years of age differed in their meconium microbiome from those with normal weight, having a higher proportion of Bacteroidetes phylum (29% vs 15%, P = .013). Using the machine‐learning approach, the gut microbiome at birth predicted subsequent overweight with area under the curve 0.70 (SD 0.04). A lower proportion of Staphylococcus at birth was associated with greater length/height at 1 year (ß = −.68, P = .029) and 2 years of age (β = −.74, P = .030).

Conclusions: The microbiome of the first‐pass meconium predicted subsequent overweight at the age of 3 years. The association between the gut microbiome and overweight appears to start already during pregnancy and at birth.

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Series: Pediatric obesity
ISSN: 2047-6302
ISSN-E: 2047-6310
ISSN-L: 2047-6302
Volume: 15
Issue: 11
Article number: e12680
DOI: 10.1111/ijpo.12680
OADOI: https://oadoi.org/10.1111/ijpo.12680
Type of Publication: A1 Journal article – refereed
Field of Science: 3123 Gynaecology and paediatrics
Subjects:
Funding: Emil Aaltonen Foundation; UniOGS Graduate School, University of Oulu; Stiftelsen Alma och K. A. Snellman Foundation; Juho Vainio Foundation; Academy of Finland; Pediatric Research Foundation.
Copyright information: © 2020 The Authors. Pediatric Obesity published by John Wiley & Sons Ltd on behalf of World Obesity Federation. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
  https://creativecommons.org/licenses/by/4.0/