Pyry M. Uotila, Siria A. Lemma, Kirsi-Maria Haapasaari, Katja Porvari, Sini Skarp, Ylermi Soini, Esa Jantunen, Taina Turpeenniemi-Hujanen & Outi Kuittinen (2020) Prognostic significance of Twist, ZEB1 and Slug in peripheral T-cell lymphomas, Hematology, 25:1, 241-246, DOI: 10.1080/16078454.2020.1780754
Prognostic significance of Twist, ZEB1 and Slug in peripheral T-cell lymphomas
|Author:||Uotila, Pyry M.1,2; Lemma, Siria A.1,2; Haapasaari, Kirsi-Maria3;|
1Department of Oncology and Radiotherapy, Oulu University Hospital and University of Oulu, Oulu, Finlandl
2Medical Research Center and Unit of Translational Medicine, Oulu University Hospital and University of Oulu, Oulu, Finland
3Department of Pathology, Oulu University Hospital and University of Oulu, Oulu, Finland
4Faculty of Biochemistry and Molecular Medicine, Oulu University Hospital and University of Oulu, Oulu, Finland
5Biocenter Oulu, Oulu University, Oulu, Finland
6Department of Clinical Pathology and Forensic Medicine, Cancer Center of Eastern Finland, Kuopio University Hospital and University of Eastern Finland, Kuopio, Finland
7Department of Medicine, Kuopio University Hospital, University of Eastern Finland, Kuopio, Finland
|Online Access:||PDF Full Text (PDF, 1.6 MB)|
|Persistent link:|| http://urn.fi/urn:nbn:fi-fe2020090267261
|Publish Date:|| 2020-09-02
Objectives: To investigate the protein expression of the epithelial-mesenchymal transition-inducing transcription factors (TFs) Twist, ZEB1 and Slug in peripheral T-cell lymphomas (PTCL) and their correlation with clinical parameters.
Methods: The expression of these TFs was studied in 53 diagnostic biopsy specimens of several different PTCL subtypes with immunohistochemistry. Patient data were retrospectively collected from patient records and a statistical analysis was performed.
Results: All three TFs were widely expressed. ZEB1 and Slug had correlations with clinical outcome. In all PTCL cases, high nuclear ZEB1 percentage correlated with a favorable progression-free survival (PFS) (3-year PFS: 70% vs. 34%; P = 0.010) and strong nuclear Slug intensity correlated with an unfavorable PFS (3-year PFS: 17% vs. 62%; P = 0.036).
Discussion: The correlations between PFS and ZEB1 or Slug protein expression have not previously been established in PTCLs. The impact of ZEB1 and Slug expression on prognosis differed from our findings in DLBCL and the impact of ZEB1 expression was in line with current studies on mycosis fungoides and sézary syndrome. The findings may be explained by the roles these TFs play in hematopoiesis.
Conclusion: ZEB1 and Slug may have potential clinical value for evaluating prognosis in PTCLs. The study size was small and heterogenous, and larger studies are warranted.
|Pages:||241 - 246|
|Type of Publication:||
A1 Journal article – refereed
|Field of Science:||
This work was supported by the Cancer Society of Finland; the Orion Research Foundation; the Finnish Medical Society Duodecim; the Finnish Cultural Foundation; the Finnish Anti-Tuberculosis Association and the Ida Montin Foundation.
© 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis GroupThis is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricteduse, distribution, and reproduction in any medium, provided the original work is properly cited.