Bahri Khomami, M, Joham, AE, Boyle, JA, et al. The role of maternal obesity in infant outcomes in polycystic ovary syndrome—A systematic review, meta‐analysis, and meta‐regression. Obesity Reviews. 2019; 20: 842– 858. https://doi.org/10.1111/obr.12832
The role of maternal obesity in infant outcomes in polycystic ovary syndrome : a systematic review, meta‐analysis, and meta‐regression
|Author:||Khomami, Mahnaz Bahri1; Joham, Anju E.1,2; Boyle, Jacqueline A.1,3;|
1Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia
2Diabetes and Vascular Medicine Unit, Monash Health, Melbourne, Australia
3Department of Obstetrics and Gynaecology, Monash Health, Melbourne, Australia
4Department of Obstetrics and Gynecology, PEDEGO Research Unit, Medical Research Center, Oulu University Hospital, University of Oulu, Oulu, Finland
5Monash Partners Academic Health Sciences Centre, Melbourne, Australia
|Online Access:||PDF Full Text (PDF, 0.8 MB)|
|Persistent link:|| http://urn.fi/urn:nbn:fi-fe2020091669825
John Wiley & Sons,
|Publish Date:|| 2020-09-16
Polycystic ovary syndrome (PCOS) is associated with worsened pregnancy and infant outcomes, higher body mass index (BMI), and longitudinal weight gain. Despite most of the clinical features of PCOS being risk factors for worsened infant outcomes in the general population, their impact on infant outcomes in PCOS is unknown. We aimed to investigate the association of PCOS with infant outcomes considering maternal adiposity, other known risk factors, and potential confounders. The meta‐analyses included 42 studies in 7041 women with PCOS and 63 722 women without PCOS. PCOS was associated with higher gestational weight gain (GWG) and with higher preterm birth and large for gestational age and with lower birth weight with this association varying by geographic continent, PCOS phenotypes, and study quality. However, PCOS was associated with none of these outcomes on BMI‐matched studies. Gestational diabetes was significantly associated with an increased preterm birth on meta‐regression. We report for the first time that GWG is higher in PCOS. Infant outcomes vary by geographic continent and study quality but are similar in BMI‐matched women with and without PCOS. This suggests that infant outcomes in PCOS may be related to maternal obesity. These novel findings warrant future studies in PCOS investigating screening and management of infant outcomes with consideration of maternal obesity.
|Pages:||842 - 858|
|Type of Publication:||
A2 Review article in a scientific journal
|Field of Science:||
3123 Gynaecology and paediatrics
A Monash University International Postgraduate Research Scholarship supports M.B.K. An NHMRC Early Career Fellowship of Australia supports A.E.J. An NHMRC Career Development Fellowship of Australia supports J.A.B. The Sigrid Juselius Foundation, the Finnish Medical Foundation, the Academy of Finland supports T.P., and H.J.T. is supported by a fellowship from the National Health and Medical Research Council of Australia. A Future Leader Fellowship from the National Heart Foundation of Australia supports L.J.M.
© 2019 World Obesity Federation. This is the peer reviewed version of the following article: Bahri Khomami, M, Joham, AE, Boyle, JA, et al. The role of maternal obesity in infant outcomes in polycystic ovary syndrome—A systematic review, meta‐analysis, and meta‐regression. Obesity Reviews. 2019; 20: 842– 858, which has been published in final form at https://doi.org/10.1111/obr.12832. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.