Bahri Khomami, M, Joham, AE, Boyle, JA, et al. Increased maternal pregnancy complications in polycystic ovary syndrome appear to be independent of obesity—A systematic review, meta‐analysis, and meta‐regression. Obesity Reviews. 2019; 20: 659– 674. https://doi.org/10.1111/obr.12829
Increased maternal pregnancy complications in polycystic ovary syndrome appear to be independent of obesity : a systematic review, meta‐analysis, and meta‐regression
|Author:||Khomami, Mahnaz Bahri1; Joham, Anju E.1,2; Boyle, Jacqueline A.1,3;|
1Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia
2Diabetes and Vascular Medicine Unit, Monash Health, Melbourne, Australia
3Department of Obstetrics and Gynaecology, Monash Health, Melbourne, Australia
4Department of Obstetrics and Gynaecology, PEDEGO Research Unit, Medical Research Center, Oulu University Hospital, University of Oulu, Oulu, Finland
5Monash Partners Academic Health Sciences Centre, Melbourne, Australia
|Online Access:||PDF Full Text (PDF, 1.7 MB)|
|Persistent link:|| http://urn.fi/urn:nbn:fi-fe2020091769941
John Wiley & Sons,
|Publish Date:|| 2020-09-17
Polycystic ovary syndrome (PCOS) is associated with an increased risk of maternal pregnancy and delivery complications. However, the impact of clinical features of PCOS and other potential risk factors in PCOS is still unknown. We aimed to investigate the association of PCOS with maternal pregnancy and delivery complications with consideration of risk factors and potential confounders. The meta‐analysis included 63 studies. PCOS was associated with higher miscarriage, gestational diabetes mellitus, gestational hypertension, pre‐eclampsia, induction of labour, and caesarean section. The association of PCOS with these outcomes varied by geographic continent, PCOS phenotypes, and study quality. Pre‐eclampsia and induction of labour were not associated with PCOS on body mass index‐matched studies. No outcome was associated with PCOS on assisted pregnancies. Age was significantly associated with higher miscarriage on meta‐regression. There were no studies assessing perinatal depression. We confirm that PCOS is associated with an increased risk of maternal pregnancy and delivery complications. The association of PCOS with the outcomes is worsened in hyperandrogenic PCOS phenotypes, in specific geographic continents, and in the highest quality studies but disappears in assisted pregnancies. Future studies in PCOS are warranted to investigate proper timing for screening and prevention of maternal pregnancy and delivery complications with consideration of clinical features of PCOS.
|Pages:||659 - 674|
|Type of Publication:||
A2 Review article in a scientific journal
|Field of Science:||
3123 Gynaecology and paediatrics
A Monash University International Postgraduate Research Scholarship supports M.B.K. An NHMRC Early Career Fellowship of Australia supports A.E.J. An NHMRC Career Development Fellowship of Australia supports J.A.B. The Sigrid Juselius Foundation, the Finnish Medical Foundation, the Academy of Finland support T. P., and H.J.T. is supported by a fellowship from the National Health and Medical Research Council of Australia. A Future Leader Fellowship from the National Heart Foundation of Australia supports L.J.M.
© 2019 World Obesity Federation. This is the peer reviewed version of the following article: Bahri Khomami, M, Joham, AE, Boyle, JA, et al. Increased maternal pregnancy complications in polycystic ovary syndrome appear to be independent of obesity—A systematic review, meta‐analysis, and meta‐regression. Obesity Reviews. 2019; 20: 659– 674, which has been published in final form at https://doi.org/10.1111/obr.12829. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.