Turunen, A., Partanen, A., Valtola, J., Ropponen, A., Siitonen, T., Kuittinen, O., Kuitunen, H., Putkonen, M., Sankelo, M., Keskinen, L., Savolainen, E.‐R., Pyörälä, M., Kuittinen, T., Silvennoinen, R., Penttilä, K., Sikiö, A., Vasala, K., Mäntymaa, P., Pelkonen, J., Varmavuo, V. and Jantunen, E. (2020), CD34+ cell mobilization, blood graft composition, and posttransplant recovery in myeloma patients compared to non‐Hodgkinʼs lymphoma patients: results of the prospective multicenter GOA study. Transfusion, 60: 1519-1528. doi:10.1111/trf.15820
CD34+ cell mobilization, blood graft composition, and posttransplant recovery in myeloma patients compared to non‐Hodgkinʼs lymphoma patients : results of the prospective multicenter GOA study
|Author:||Turunen, Antti1,2; Partanen, Anu1; Valtola, Jaakko1;|
1Department of Medicine, Kuopio University Hospital, Kuopio, Finland
2Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland
3Department of Clinical Microbiology, University of Eastern Finland, Kuopio, Finland
4Department of Medicine, Oulu University Hospital, Oulu, Finland
5Department of Oncology, Kuopio University Hospital, Kuopio, Finland
6Department of Oncology, Oulu University Hospital, Oulu, Finland
7Department of Medicine, Turku University Hospital, Turku, Finland
8Department of Internal Medicine, Tampere University Hospital, Tampere, Finland
9Department of Oncology, Tampere University Hospital, Tampere, Finland
10Nordlab, Medical Research Center Oulu, Oulu University Hospital, Oulu, Finland
11Hematology, Comprehensive Cancer Center, Helsinki University Hospital, Helsinki, Finland
12Finnish Medicines Agency, Kuopio, Finland
13Department of Medicine, Savonlinna Central Hospital, Savonlinna, Finland
14Department of Medicine, Central Hospital of Central Finland, Jyväskylä, Finland
15Department of Oncology, Central Hospital of Central Finland, Jyväskylä, Finland
16Laboratory Centre of Eastern Finland, Kuopio, Finland
17Department of Medicine, Kymenlaakso Central Hospital, Kotka, Finland
18Department of Medicine, North Carelia Hospital District, Joensuu, Finland
|Online Access:||PDF Full Text (PDF, 0.4 MB)|
|Persistent link:|| http://urn.fi/urn:nbn:fi-fe2020091769957
John Wiley & Sons,
|Publish Date:|| 2020-09-17
Background: Autologous stem cell transplantation is an established treatment option for patients with multiple myeloma (MM) or non‐Hodgkinʼs lymphoma (NHL).
Study design and methods: In this prospective multicenter study, 147 patients with MM were compared with 136 patients with NHL regarding the mobilization and apheresis of blood CD34+ cells, cellular composition of infused blood grafts, posttransplant recovery, and outcome.
Results: Multiple myeloma patients mobilized CD34+ cells more effectively (6.3 × 10⁶/kg vs. 3.9 × 10⁶/kg, p = 0.001). The proportion of poor mobilizers (peak blood CD34+ cell count <20 × 10⁶/L) was higher in NHL patients (15% vs. 3%, p < 0.001). Plerixafor was added to rescue the mobilization failure in 17 MM patients (12%) and in 35 NHL patients (26%; p = 0.002). The infused grafts contained more natural killer (NK) and CD19+ cells in MM patients. Blood platelet and NK‐cell counts were higher in MM patients posttransplant. Early treatment‐related mortality was low in both groups, but NHL patients had a higher late (>100 days) nonrelapse mortality (NRM; 6% vs. 0%, p = 0.003).
Conclusions: Non‐Hodgkinʼs lymphoma and MM patients differ in terms of mobilization of CD34+ cells, graft cellular composition, and posttransplant recovery. Thus, the optimal graft characteristics may also be different.
|Pages:||1519 - 1528|
|Type of Publication:||
A1 Journal article – refereed
|Field of Science:||
This study was supported by North Savo Hospital District VTR and EVO Funds and also Sanofi Genzyme. Dr. Turunen is grateful for the grants provided by North Savo Hospital District Research Fund, Blood Disease Research Foundation and The Finnish Medical Foundation.
© 2020 The Authors. Transfusion published by Wiley Periodicals, Inc. on behalf of AABB. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.