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Body composition and changes in health-related quality of life in older age : a 10-year follow-up of the Helsinki Birth Cohort Study |
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| Author: | Mikkola, Tuija M.1,2; Kautiainen, Hannu1,3; von Bonsdorff, Mikaela B.1,4; |
| Organizations: |
1Folkhälsan Research Center, Helsinki, Finland 2Clinicum, Faculty of Medicine, University of Helsinki, Helsinki, Finland 3Primary Health Care Unit, Kuopio University Hospital, Kuopio, Finland
4Gerontology Research Center, Faculty of Sport and Health Sciences, University of Jyväskylä, Jyvaskyla, Finland
5Public Health Promotion Unit, National Institute for Health and Welfare, Helsinki, Finland 6Department of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, Helsinki, Finland 7PEDEGO Research Unit, MRC Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland 8Department of Clinical and Molecular Medicine, Norwegian University for Science and Technology, Trondheim, Norway 9Children’s Hospital, Helsinki University Hospital and University of Helsinki, Helsinki, Finland 10Singapore Institute for Clinical Sciences, Agency for Science, Technology, and Research, Singapore, Singapore 11Department of Obstetrics & Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore |
| Format: | article |
| Version: | published version |
| Access: | open |
| Online Access: | PDF Full Text (PDF, 0.7 MB) |
| Persistent link: | http://urn.fi/urn:nbn:fi-fe2020091769959 |
| Language: | English |
| Published: |
Springer Nature,
2020
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| Publish Date: | 2020-09-17 |
| Description: |
AbstractPurpose: Most studies examining the associations between body composition and health-related quality of life (HRQoL) in older age have been cross-sectional and analyzed only fat or lean mass. Hence, it is poorly known whether fat and lean mass are independently associated with subsequent changes in HRQoL. We investigated whether baseline lean and fat mass are associated with changes in HRQoL over a 10-year period in older adults. Methods: We studied 1044 men and women from the Helsinki Birth Cohort Study (age 57–70 years at baseline). Bioelectrical impedance analysis was used to derive baseline fat mass index (FMI, fat mass/height²) and lean mass index (lean mass/height²), dichotomized at sex-specific medians. HRQoL was assessed using RAND 36-item Health Survey at baseline and follow-up 10 years later. Results: When controlled for lean mass and adjusted for potential confounders, high baseline FMI was associated with a greater decline in general health (standardized regression coefficient [β] = − 0.13, p = 0.001), physical functioning (β = − 0.11, p = 0.002), role physical (β = − 0.13, p = 0.003), vitality (β = − 0.08, p = 0.027), role emotional (β = − 0.12, p = 0.007), and physical component score (β = − 0.14, p < 0.001). High baseline FMI was also associated with low HRQoL in all physical domains at baseline (β: from − 0.38 to − 0.10). Lean mass was not strongly associated with HRQoL at baseline or change in HRQoL. Conclusion: In older community-dwelling adults, higher fat mass is, independent of lean mass, associated with lower physical HRQoL and greater decline in HRQoL. Prevention of adiposity may contribute to preservation of a good quality of life in older age. see all
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| Series: |
Quality of life research |
| ISSN: | 0962-9343 |
| ISSN-E: | 1573-2649 |
| ISSN-L: | 0962-9343 |
| Volume: | 29 |
| Issue: | 8 |
| Pages: | 2039 - 2050 |
| DOI: | 10.1007/s11136-020-02453-1 |
| OADOI: | https://oadoi.org/10.1007/s11136-020-02453-1 |
| Type of Publication: |
A1 Journal article – refereed |
| Field of Science: |
3142 Public health care science, environmental and occupational health |
| Subjects: | |
| Funding: |
Open access funding provided by University of Helsinki including Helsinki University Central Hospital. This work was supported by Emil Aaltonen Foundation; Finnish Foundation for Diabetes Research; Foundation for Pediatric Research, Novo Nordisk Foundation; Signe and Ane Gyllenberg Foundation; Sigrid Jusélius Foundation; Samfundet Folkhälsan; Finska Läkaresällskapet; Liv och Hälsa; European Commission within the 7th Framework Programme (DORIAN, Grant Agreement No. 278603); and European Union Horizon 2020 programme (LifeCycle Grant No. 733206, DYNAHEALTH Grant No. 633595 and RECAP Grant No. SC1-2016-RTD-733180). The Academy of Finland supported EK (Grant Nos. 127437, 129306, 130326, 134791, 263924 and 274794); and J.G.E. (Grant Nos. 129369, 129907, 135072, 129255, and 126775). |
| EU Grant Number: |
(733206) LIFECYCLE - Early-life stressors and LifeCycle health (633595) DYNAHEALTH - Understanding the dynamic determinants of glucose homeostasis and social capability to promote Healthy and active aging |
| Copyright information: |
© The Author(s) 2020. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
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https://creativecommons.org/licenses/by/4.0/ |