University of Oulu

Vaskivuo, L., Hokkanen, L., Hänninen, T., Antikainen, R., Bäckman, L., Laatikainen, T., Paajanen, T., Stigsdotter-Neely, A., Strandberg, T., Tuomilehto, J., Soininen, H., Kivipelto, M., Ngandu, T. (2019) Self and Informant Memory Reports in FINGER: Associations with Two-Year Cognitive Change. Journal of Alzheimer's Disease, 71 (3), 785-795. doi:doi: 10.3233/JAD-190133

Self and informant memory reports in FINGER : associations with two-year cognitive change

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Author: Vaskivuo, Laura1,2; Hokkanen, Laura2; Hänninen, Tuomo3;
Organizations: 1Public Health Promotion Unit, National Institute for Health and Welfare, Helsinki, Finland
2Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Finland
3Neurocenter/ Neurology, Kuopio University Hospital, Finland
4University of Oulu, Center for Life Course health Research, Oulu, Finland
5Medical Research Center Oulu, Oulu University Hospital and Oulu City Hospital, Oulu, Finland
6Aging Research Center, Karolinska Institutet-Stockholm University, Stockholm, Sweden
7Institute of Public Health and Clinical Nutrition, University of Eastern Finland; Kuopio, Finland
8Hospital District of North Karelia, Joensuu, Finland
9Finnish Institute of Occupational Health, Helsinki, Finland
10Department of Psychology, Umeå University, Umeå, Sweden and Department of Social and Psychological Sciences, Karlstad university, Karlstad, Sweden
11University of Helsinki, Clinicum, and Helsinki University Hospital, Helsinki, Finland
12South Ostrobothnia Central Hospital, Seinäjoki, Finland and Department of Public Health, University of Helsinki, Helsinki, Finland
13Dasman Diabetes Institute, Kuwait City, Kuwait, Danube University Kerms, Krems, Austria and Kind Abdulaziz University, Jeddah, Saudi Arabia
14Institute of Clinical Medicine/Neurology, University of Eastern Finland, Kuopio, Finland
15Karolinska Institutet Center for Alzheimer Research, Stockholm, Sweden
Format: article
Version: accepted version
Access: open
Online Access: PDF Full Text (PDF, 0.7 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe2020092275509
Language: English
Published: IOS Press, 2019
Publish Date: 2020-09-22
Description:

Abstract

Background:Subjective memory complaints (SMCs) may be the first sign of cognitive decline in aging. Objective:To examine whether SMCs reported by oneself and informant predict cognitive change over 2 years among at-risk elderly people, and to determine the relationship of different types of SMCs (prospective and retrospective memory complaints) and change in cognitive function. Methods:This investigation is part of the FINGER project, which is a multicenter randomized controlled trial aiming at preventing cognitive decline in cognitively healthy older adults with increased risk of dementia. A subsample of 303 control-group participants (aged 60–80 years) and their informants (n = 261) rated the frequency of SMCs, using the Prospective and Retrospective Memory Questionnaire (PRMQ). Cognitive performance was measured at baseline and at 1- and 2-year follow-up visits using a neuropsychological test battery. Results:Participants who reported more SMCs improved less in global cognition, executive function, and memory during the subsequent 2 years in the fully-adjusted analyses. Self-reported retrospective memory problems predicted less improvement in all cognitive domains, whereas prospective memory problems did not. Informant-reported memory problems were not linked to subsequent change in cognition. Conclusion:Our results indicate that self-reported SMCs, measured with PRMQ, predict future cognitive change in several cognitive domains. By contrast, reports by informants were not linked to changes in cognition. Among cognitively healthy at-risk elderly individuals, the persons themselves observe more easily problems relevant for their future cognitive trajectories than their informants.

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Series: Journal of Alzheimer's disease
ISSN: 1387-2877
ISSN-E: 1875-8908
ISSN-L: 1387-2877
Volume: 71
Issue: 3
Pages: 785 - 795
DOI: 10.3233/JAD-190133
OADOI: https://oadoi.org/10.3233/JAD-190133
Type of Publication: A1 Journal article – refereed
Field of Science: 3121 General medicine, internal medicine and other clinical medicine
Subjects:
Funding: This research was supported by grants from the Academy of Finland’s Responding to Public Health Challenges Research Programme (SALVE), Academy of Finland grants 259615, 278457, 287490, 294061, 305810; La Carita Foundation, Juho Vainio Foundation, Novo Nordisk Foundation, Finnish Social Insurance Institution, Ministry of Education and Culture Research Grant, and EVO/VTR grants of University Hospitals of Kuopio, Oulu and Turku, Seinäjoki Central hospital and Oulu City Hospital for FINGER project, Swedish Research Council; Alzheimer's Research & Prevention Foundation USA; AXA Research Fund; the Sheika Salama Bint Hamdan Alahyan Foundation, Finnish Medical Foundation, Academy of Finland for Joint Program of Neurodegenerative Disorders – prevention (MIND-AD), an Alexander von Humboldt Research Award, Knut and Alice Wallenberg Foundation Sweden, Center for Innovative Medicine (CIMED) at Karolinska Institutet Sweden, Stiftelsen Stockholms sjukhem Sweden, Konung Gustaf V:s och Drottning Victorias Frimurarstiftelse Sweden, af Jochnick Foundation Sweden as well as personal grants from Finnish Brain foundation sr (LV).
Copyright information: © 2019 Journal of Alzheimer's Disease. This is a post-peer-review, pre-copyedit version of an article published in Journal of Alzheimer's Disease. The final authenticated version is available online at https://doi.org/10.3233/JAD-190133.