University of Oulu

Tatiana Avsievich, Ruixue Zhu, Alexey Popov, Alexander Bykov, Igor Meglinski, The advancement of blood cell research by optical tweezers, Reviews in Physics, Volume 5, 2020, 100043, ISSN 2405-4283, https://doi.org/10.1016/j.revip.2020.100043

The advancement of blood cell research by optical tweezers

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Author: Avsievich, Tatiana1; Zhu, Ruixue1; Popov, Alexey2;
Organizations: 1Optoelectronics and Measurement Techniques, University of Oulu, 90570, Finland
2VTT Technical Research Centre of Finland, Oulu 90590, Finland
3Interdisciplinary Laboratory of Biophotonics, National Research Tomsk State University, Tomsk 634050, Russia
4Institute of Engineering Physics for Biomedicine (PhysBio), National Research Nuclear University (MEPhI), Moscow 115409, Russia
5School of Engineering and Applied Science, Aston University, Birmingham B4 7ET, UK
6School of Life and Health Sciences, Aston University, Birmingham B4 7ET, UK
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 4.8 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe2020092475665
Language: English
Published: Elsevier, 2020
Publish Date: 2020-09-24
Description:

Abstract

Demonstration of the light radiation pressure on a microscopic level by A. Ashkin led to the invention of optical tweezers (OT). Applied in the studies of living systems, OT have become a preferable instrument for the noninvasive study of microobjects, allowing manipulation and measurement of the mechanical properties of molecules, organelles, and cells. In the present paper, we overview OT applications in hemorheological research, placing emphasis on red blood cells but also discussing OT applications for the investigation of the biomechanics of leukocytes and platelets. Blood properties have always served as a primary parameter in medical diagnostics due to the interconnection with the physiological state of an organism. Despite blood testing being a well-established procedure of conventional medicine, there are still many complex processes that must be unraveled to improve our understanding and contribute to future medicine. OT are advancing single-cell research, promising new insights into individual cell characteristics compared to the traditional approaches. We review the fundamental and practical findings revealed in blood research through the optical manipulation, stretching, guiding, immobilization, and inter-/intracellular force measurements of single blood cells.

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Series: Reviews in physics
ISSN: 2405-4283
ISSN-L: 2405-4283
Volume: 5
Article number: 100043
DOI: 10.1016/j.revip.2020.100043
OADOI: https://oadoi.org/10.1016/j.revip.2020.100043
Type of Publication: A1 Journal article – refereed
Field of Science: 1182 Biochemistry, cell and molecular biology
Subjects:
Funding: Tatiana Avsievich acknowledges Suomen Kulttuurirahasto (Grant no. 00190188, 2021). Ruixue Zhu acknowledges the China Scholarship Council (CSC no. 201706410089, R.Z.) and Tauno Tnning Foundation (Grant no. 20190104, R.Z.). Alexey Popov acknowledges partial support from the Academy of Finland (projects 32126, 334531). Professor Meglinski acknowledges partial support from the INFOTECH, Academy of Finland (project 325097), the MEPhI Academic Excellence Project (Contract no. 02.a03.21.0005 ) and the National Research Tomsk State University Academic D.I. Mendeleev Fund Program. The authors also acknowledge the contribution of the Russian Science Foundation (Project: 19-72-30012).
Academy of Finland Grant Number: 32126
334531
325097
Detailed Information: 32126 (Academy of Finland Funding decision)
334531 (Academy of Finland Funding decision)
325097 (Academy of Finland Funding decision)
Copyright information: © 2020 The Author(s). Published by Elsevier B.V. his is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/).
  https://creativecommons.org/licenses/by/4.0/