University of Oulu

Ivanov D, Dremin V,Bykov A, et al. Colon cancer detection by usingPoincaré sphere and 2D polarimetric mapping ofex vivo colon samples.J. Biophotonics. 2020;13:e202000082.https://doi.org/10.1002/jbio.202000082

Colon cancer detection by using Poincaré sphere and 2D polarimetric mapping of ex vivo colon samples

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Author: Ivanov, Deyan1; Dremin, Viktor2,3; Bykov, Alexander3;
Organizations: 1Institute of Electronics, Bulgarian Academy of Sciences, Sofia, Bulgaria
2Research & Development Center of Biomedical Photonics, Orel State University, Orel, Russia
3Optoelectronics and Measurement Techniques unit, University of Oulu, Oulu, Finland
4Biology Faculty, Saratov State University, Saratov, Russia
5VTT Technical Research Centre of Finland, Oulu, Finland
6LPICM, Ecole Polytechnique, Palaiseau, France
7Interdisciplinary Laboratory of Biophotonics, National Research Tomsk State University, Tomsk, Russia
8Institute of Engineering Physics for Biomedicine (PhysBio), National Research Nuclear University - MEPhI, Moscow, Russia
9School of Engineering and Applied Science, Aston University, Birmingham, UK
10School of Life and Health Sciences, Aston University, Birmingham, UK
Format: article
Version: accepted version
Access: embargoed
Persistent link: http://urn.fi/urn:nbn:fi-fe2020101584163
Language: English
Published: John Wiley & Sons, 2020
Publish Date: 2021-05-10
Description:

Abstract

This work is dedicated to the diagnosis and grading of colon cancer by a combined use of Poincaré sphere and 2D Stokes vector polarimetry mapping approaches. The major challenge consists in exploring the applicability of polarized light for noninvasive screening of the histological abnormalities within the samples of biological tissues. Experimental studies were conducted in ex vivo colon sample, excised after surgical procedure for colon tumor removal of G2‐adenocarcinoma lesion. Polarimetric measurements in linear and circular regime were carried via personally developed polarimetric, optical set‐up, using supercontinuous fiber laser with irradiation fixed at 635 nm. We apply the Poincaré sphere and two‐dimensional Stokes vector scanning approach for screening the corresponding tissue samples. A comparison between linear and circular polarization states is made both for quantitative and qualitative evaluations. It is shown that circular polarization has better diagnostic capabilities than linear polarization, with higher dynamic ranges of the polarimetric parameters and better values of the diagnostic quantities. In addition to the standard polarimetry parameters, utilized as essential diagnostic markers, we apply statistical analysis to obtain more detailed information in frame of the applied diagnostic.

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Series: Journal of biophotonics
ISSN: 1864-063X
ISSN-E: 1864-0648
ISSN-L: 1864-063X
Volume: 13
Issue: 8
Article number: e202000082
DOI: 10.1002/jbio.202000082
OADOI: https://oadoi.org/10.1002/jbio.202000082
Type of Publication: A1 Journal article – refereed
Field of Science: 213 Electronic, automation and communications engineering, electronics
217 Medical engineering
Subjects:
Funding: The polarimetric investigations were supported by NSFB‐MES project #KP06‐N28/11/14.12.2018. The authors also acknowledge the support of the Academy of Finland (grants: 314369 and 325097). This study was also supported by the Russian Science Foundation under projects No. 19‐79‐00082 (experimental data collection) and project No. 18‐15‐00139 (samples selection and preparation). Professor Meglinski acknowledges support from MEPhI Academic Excellence Project (Contract No. 02.a03.21.0005) and the National Research Tomsk State University Academic D.I. Mendeleev Fund Program. This project has also received funding from the ATTRACT project funded by the EU under Grant Agreement 777222. T. Novikova, R.Ossikovski and E. Borisova acknowledged the contribution from bilateral project POLHIS, program Campus France PHC RILA, n 38660WH & DNTS/France 01/7‐09/05/2017 “Polarization optical histology of tumors.” Authors are sincerely thankful to Ms. Mariia Borovkova for the contribution in preparation of Figure 3.
Copyright information: © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This is the peer reviewed version of the following article: Ivanov D, Dremin V,Bykov A, et al. Colon cancer detection by usingPoincaré sphere and 2D polarimetric mapping ofex vivo colon samples.J. Biophotonics. 2020;13:e202000082.https://doi.org/10.1002/jbio.202000082, which has been published in final form at https://doi.org/10.1002/jbio.202000082. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.