Pan-cancer analysis of the genomic alterations and mutations of the matrisome
|Author:||Izzi, Valerio1,2; Davis, Martin N.3; Naba, Alexandra3,4|
1Faculty of Biochemistry and Molecular Medicine, University of Oulu, FI-90014 Oulu, Finland
2Finnish Cancer Institute, 00130 Helsinki, Finland
3Department of Physiology and Biophysics, University of Illinois at Chicago, Chicago, IL 60612, USA
4University of Illinois Cancer Center, Chicago, IL 60612, USA
|Online Access:||PDF Full Text (PDF, 2.8 MB)|
|Persistent link:|| http://urn.fi/urn:nbn:fi-fe2020101984324
Multidisciplinary Digital Publishing Institute,
|Publish Date:|| 2020-10-19
The extracellular matrix (ECM) is a master regulator of all cellular functions and a major component of the tumor microenvironment. We previously defined the “matrisome” as the ensemble of genes encoding ECM proteins and proteins modulating ECM structure or function. While compositional and biomechanical changes in the ECM regulate cancer progression, no study has investigated the genomic alterations of matrisome genes in cancers and their consequences. Here, mining The Cancer Genome Atlas (TCGA) data, we found that copy number alterations and mutations are frequent in matrisome genes, even more so than in the rest of the genome. We also found that these alterations are predicted to significantly impact gene expression and protein function. Moreover, we identified matrisome genes whose mutational burden is an independent predictor of survival. We propose that studying genomic alterations of matrisome genes will further our understanding of the roles of this compartment in cancer progression and will lead to the development of innovative therapeutic strategies targeting the ECM.
|Pages:||1 - 21|
|Type of Publication:||
A1 Journal article – refereed
|Field of Science:||
1182 Biochemistry, cell and molecular biology
This work was supported by a start-up fund from the Department of Physiology and Biophysics at the University of Illinois at Chicago awarded to AN and by an Academy of Finland R´Life grant (329742) and the K. Albin Johansson Cancer Research Fellowship from the Finnish Cancer Institute awarded to VI. The authors acknowledge the Research Open Access Publishing (ROAAP) Fund of the University of Illinois at Chicago for financial support towards the open access publishing fee for this article.
|Academy of Finland Grant Number:||
329742 (Academy of Finland Funding decision)
© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).