Kulmala, J., Ngandu, T., Havulinna, S., Levälahti, E., Lehtisalo, J., Solomon, A., Antikainen, R., Laatikainen, T., Pippola, P., Peltonen, M., Rauramaa, R., Soininen, H., Strandberg, T., Tuomilehto, J., & Kivipelto, M. (2019). The Effect of Multidomain Lifestyle Intervention on Daily Functioning in Older People. Journal of the American Geriatrics Society, 67(6), 1138–1144. https://doi.org/10.1111/jgs.15837
The effect of multidomain lifestyle intervention on daily functioning in older people
|Author:||Kulmala, Jenni1,2,3; Ngandu, Tiia1,2; Havulinna, Satu4;|
1Public Health Promotion Unit, National Institute for Health and Welfare, Helsinki, Finland
2Division of Clinical Geriatrics, Center for Alzheimer Research, Care Sciences and Society (NVS), Karolinska Institutet, Stockholm, Sweden
3School of Health Care and Social Work, Seinäjoki University of Applied Sciences, Seinäjoki, Finland
4Ageing, Disability and Functioning Unit, National Institute for Health and Welfare, Helsinki, Finland
5Institute of Clinical Medicine/Neurology, University of Eastern Finland, Kuopio, Finland
6Center for Life Course Health Research, University of Oulu, Oulu, Finland
7Medical Research Center Oulu, Oulu University Hospital, Oulu, Finland
8Oulu City Hospital, Oulu, Finland
9Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland
10Joint Municipal Authority for North Karelia Social and Health Services (Siun Sote), Joensuu, Finland
11Seinäjoki Health Centre, Seinäjoki, Finland
12Kuopio Research Institute of Exercise Medicine, Kuopio, Finland
13Neurocenter, Department of Neurology, Kuopio University Hospital, Kuopio, Finland
14University of Helsinki and Helsinki University Hospital, Helsinki, Finland
15Department of Public Health, University of Helsinki, Helsinki, Finland
16National School of Public Health, Madrid, Spain
17Neuroepidemiology and Ageing Research Unit, School of Public Health, Imperial College London, London, United Kingdom
|Online Access:||PDF Full Text (PDF, 0.5 MB)|
|Persistent link:|| http://urn.fi/urn:nbn:fi-fe2020102085776
John Wiley & Sons,
|Publish Date:|| 2020-02-26
Objective: To investigate the effect of a 2‐year multidomain lifestyle intervention on daily functioning of older people.
Design: A 2‐year randomized controlled trial (ClinicalTrials.gov, NCT01041989).
Setting: Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability.
Participants: A total of 1260 older adults, with a mean age of 69 years at the baseline, who were at risk of cognitive decline.
Intervention: A multidomain intervention, including simultaneous physical activity intervention, nutritional counseling, vascular risk monitoring and management, and cognitive training and social activity.
Measurements: The ability to perform daily activities (activities of daily living [ADLs] and instrumental ADLs) and physical performance (Short Physical Performance Battery).
Results: The mean baseline ADL score was 18.1 (SD = 2.6) points; the scale ranges from 17 (no difficulties) to 85 (total ADL dependence). During the 2‐year intervention, the ADL disability score slightly increased in the control group, while in the intervention group, it remained relatively stable. Based on the latent growth curve model, the difference in the change between the intervention and control groups was −0.95 (95% confidence interval [CI] = −1.61 to −0.28) after 1 year and −1.20 (95% CI = −2.02 to −0.38) after 2 years. In terms of physical performance, the intervention group had a slightly higher probability of improvement (from score 3 to score 4; P = .041) and a lower probability of decline (from score 3 to scores 0‐2; P = .043) for chair rise compared to the control group.
Conclusions: A 2‐year lifestyle intervention was able to maintain the daily functioning of the at‐risk older population. The clinical significance of these results in this fairly well‐functioning population remains uncertain, but the study results hold promise that healthy eating, exercise, and cognitive and social activity may have favorable effects on functional independence in older people.
Journal of the American Geriatrics Society
|Pages:||1138 - 1144|
|Type of Publication:||
A1 Journal article – refereed
|Field of Science:||
3121 General medicine, internal medicine and other clinical medicine
The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability is financially supported by Academy of Finland's Responding to Public Health Challenges Research Programme; Academy of Finland grants 278,457 and 317,465 (M.K.) and 287,490, 294,061, and 319,318 (A.S.); Academy of Finland Key Project Funding 305,810; European Research Council 804,371 (A.S.); La Carita Foundation; Juho Vainio Foundation; Finnish Medical Foundation (T.N.); Finnish Social Insurance Institution; Ministry of Education and Culture Research Grant (M.K., J.K.); EVO/VTR grants of University Hospitals of Kuopio, Oulu, and Turku; Seinäjoki Central Hospital and Oulu City Hospital; Yrjö Jahnsson Foundation; Finnish Cultural Foundation; South Ostrobothnia Regional Fund; Swedish Research Council; Alzheimerfonden; Stockholm County Council; Alzheimer's Research and Prevention Foundation USA; AXA Research Fund; Knut and Alice Wallenberg Foundation Sweden; Center for Innovative Medicine at Karolinska Institutet Sweden; Stiftelsen Stockholms Sjukhem Sweden; and Konung Gustaf V:s och Drottning Victorias Frimurarstiftelse Sweden.
© 2019 The American Geriatrics Society. This is the peer reviewed version of the following article: Kulmala, J., Ngandu, T., Havulinna, S., Levälahti, E., Lehtisalo, J., Solomon, A., Antikainen, R., Laatikainen, T., Pippola, P., Peltonen, M., Rauramaa, R., Soininen, H., Strandberg, T., Tuomilehto, J., & Kivipelto, M. (2019). The Effect of Multidomain Lifestyle Intervention on Daily Functioning in Older People. Journal of the American Geriatrics Society, 67(6), 1138–1144, which has been published in final form at https://doi.org/10.1111/jgs.15837. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.