Ojala, A.K., Sintonen, H., Roine, R.P. et al. Impaired breathing, sleeping, vitality, and depression, and negative impact of L-T4 treatment characterize health-related quality of life in older people with stable CVD. Aging Clin Exp Res 32, 2041–2047 (2020). https://doi.org/10.1007/s40520-020-01537-9
Impaired breathing, sleeping, vitality, and depression, and negative impact of L-T4 treatment characterize health-related quality of life in older people with stable CVD
|Author:||Ojala, Anna K.1; Sintonen, Harri2; Roine, Risto P.3,4;|
1Endocrinology, Abdominal Center, Helsinki University Hospital and University of Helsinki, P.O. Box 340, 00290, Helsinki, Finland
2Department of Public Health, University of Helsinki, Helsinki, Finland
3Group Administration, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
4Department of Health and Social Management, University of Eastern Finland, Kuopio, Finland
5University of Helsinki, and Helsinki University Hospital, Helsinki, Finland
6Center for Life Course Health Research, University of Oulu, Oulu, Finland
|Online Access:||PDF Full Text (PDF, 0.5 MB)|
|Persistent link:|| http://urn.fi/urn:nbn:fi-fe2020110288974
|Publish Date:|| 2020-11-02
Background: Cardiovascular disease (CVD) and thyroid dysfunction are common in older people, but little is known about how they affect health-related quality of life (HRQoL).
Methods: We assessed HRQoL with the 15D instrument in 329 home-dwelling patients aged ≥ 75 years with stable CVD and compared the results to those of an age- and gender-matched general population (n = 103). We also studied the impact of age, BMI, number of medications, thyroid-stimulating hormone (TSH) concentration, levothyroxine (L-T4) substitution and Mini-Mental State Examination (MMSE) on HRQoL.
Results: Overall HRQoL was impaired in older people with stable CVD (mean 15D score 0.777 vs 0.801, p = 0.001), and also on single dimensions of breathing, sleeping, discomfort and symptoms, distress, vitality (all p < 0.001), and depression (p = 0.016) compared to the age- and gender-matched general population. Furthermore, in the patients, L-T4 substitution associated with impaired sleeping (p = 0.018) and sexual activity (p = 0.030). Moreover, MMSE points, number of medications used, age (all p < 0.001) and BMI (p = 0.009) predicted impaired HRQoL.
Conclusions: Older people with stable CVD are characterized by impaired HRQoL compared to age- and gender-matched controls. We demonstrate that this is the consequence of impaired breathing, sleeping, discomfort and symptoms, distress, vitality, and depression. L-T4 substitution has a negative impact on HRQoL in old patients with stable CVD. MMSE score, number of medications, age and BMI predict worse HRQoL.
Aging clinical and experimental research
|Pages:||2041 - 2047|
|Type of Publication:||
A1 Journal article – refereed
|Field of Science:||
3121 General medicine, internal medicine and other clinical medicine
This work was supported by Finska Läkaresällskapet (to 2018/AKO/CS-J), grants from the Helsinki University Hospital Research Funds (TYH2017138 and TYH2018223, to CS-J).
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