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Glycosylated fibronectin as a first trimester marker for gestational diabetes |
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| Author: | Alanen, Julia1; Appelblom, Heidi2; Korpimaki, Teemu2; |
| Organizations: |
1Department of Obstetrics and Gynecology, Medical Research Center, PEDEGO Research Unit, University of Oulu and Oulu University Hospital, PL 24, 90100 OYS, Oulu, Finland 2PerkinElmer, Turku, Finland 3National Institute for Health and Welfare, Helsinki, Finland |
| Format: | article |
| Version: | published version |
| Access: | open |
| Online Access: | PDF Full Text (PDF, 0.8 MB) |
| Persistent link: | http://urn.fi/urn:nbn:fi-fe2020110288990 |
| Language: | English |
| Published: |
Springer Nature,
2020
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| Publish Date: | 2020-11-02 |
| Description: |
AbstractPurpose: To evaluate the performance of first trimester maternal serum glycosylated (Sambucus nigra lectin-reactive) fibronectin in prediction of gestational diabetes mellitus (GDM). Methods: In this case–control study, first trimester maternal serum glycosylated fibronectin and fibronectin were measured in 19 women who consequently developed GDM and in 59 control women with normal pregnancy outcomes. Adiponectin was used as a reference protein to evaluate relation of glycoprotein to SNA-lectin-reactive assay format. Samples were taken during gestational weeks 9⁺⁶–11⁺⁶. Data concerning GDM was obtained from the National Institute for Health and Welfare, which records the pregnancy outcomes of all women in Finland. Results: There was no difference in maternal serum glycosylated fibronectin concentrations between women with consequent GDM [447.5 μg/mL, interquartile range (IQR) 254.4–540.9 μg/mL] and control women (437.6 μg/mL, IQR 357.1–569.1 μg/mL). Maternal serum fibronectin levels were significantly lower in GDM group (224.2 μg/mL, IQR 156.8–270.6 μg/mL), compared to the control group (264.8 μg/mL, IQR 224.6–330.6 μg/mL, p < 0.01). There was no difference in assay formats for adiponectin. Conclusion: There was no association between first trimester maternal serum glycosylated (SNA-reactive) fibronectin and GDM. see all
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| Series: |
Archives of gynecology and obstetrics |
| ISSN: | 0932-0067 |
| ISSN-E: | 1432-0711 |
| ISSN-L: | 0932-0067 |
| Volume: | 302 |
| Issue: | 4 |
| Pages: | 853 - 860 |
| DOI: | 10.1007/s00404-020-05670-8 |
| OADOI: | https://oadoi.org/10.1007/s00404-020-05670-8 |
| Type of Publication: |
A1 Journal article – refereed |
| Field of Science: |
3123 Gynaecology and paediatrics |
| Subjects: | |
| Funding: |
Open access funding provided by University of Oulu including Oulu University Hospital. PerkinElmer (Turku, Finland) sponsored the reagents for fibronectin, glycosylated fibronectin and adiponectin assays. |
| Copyright information: |
© The Author(s) 2020. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
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https://creativecommons.org/licenses/by/4.0/ |