University of Oulu

Lisanna Sinisalu, Partho Sen, Samira Salihović, Suvi M. Virtanen, Heikki Hyöty, Jorma Ilonen, Jorma Toppari, Riitta Veijola, Matej Orešič, Mikael Knip, Tuulia Hyötyläinen, Early-life exposure to perfluorinated alkyl substances modulates lipid metabolism in progression to celiac disease, Environmental Research, Volume 188, 2020, 109864, ISSN 0013-9351,

Early-life exposure to perfluorinated alkyl substances modulates lipid metabolism in progression to celiac disease

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Author: Sinisalu, Lisanna1; Sen, Partho2; Salihović, Samira1,3;
Organizations: 1School of Science and Technology, Örebro University, Örebro, Sweden
2Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland
3School of Medical Sciences, Örebro University, Örebro, Sweden
4Finnish Institute for Health and Welfare, Public Health Promotion Unit, Helsinki, Helsinki, Finland
5Unit of Health Sciences, Faculty of Social Sciences, Tampere University, Tampere, Finland
6Tampere University Hospital, Research, Development and Innovation Center, Tampere, Finland
7Tampere Center for Child Health Research, Tampere University Hospital, Tampere, Finland
8Faculty of Medicine Health Technology, Tampere University, Tampere, Finland
9Fimlab Laboratories, Pirkanmaa Hospital District, Tampere, Finland
10Immunogenetics Laboratory, Institute of Biomedicine, University of Turku, Turku, Finland
11Clinical Microbiology, Turku University Hospital, Turku, Finland
12Institute of Biomedicine, Centre for Integrative Physiology and Pharmacology, And Centre for Population Health Research, University of Turku, Turku, Finland
13Department of Pediatrics, Turku University Hospital, Turku, Finland
14Department of Paediatrics, PEDEGO Research Unit, Medical Research Centre, University of Oulu, Oulu, Finland
15Department of Children and Adolescents, Oulu University Hospital, Oulu, Finland
16Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden
17Pediatric Research Center, Children's Hospital, University of Helsinki and Helsinki University Hospital, 00290, Helsinki, Finland
18Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland
19Center for Child Health Research, Tampere University Hospital, Tampere, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 5.9 MB)
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Language: English
Published: Elsevier, 2020
Publish Date: 2020-11-02


Celiac disease (CD) is a systemic immune-mediated disorder with increased frequency in the developed countries over the last decades implicating the potential causal role of various environmental triggers in addition to gluten. Herein, we apply determination of perfluorinated alkyl substances (PFAS) and combine the results with the determination of bile acids (BAs) and molecular lipids, with the aim to elucidate the impact of prenatal exposure on risk of progression to CD in a prospective series of children prior the first exposure to gluten (at birth and at 3 months of age). Here we analyzed PFAS, BAs and lipidomic profiles in 66 plasma samples at birth and at 3 months of age in the Type 1 Diabetes Prediction and Prevention (DIPP) study (n = 17 progressors to CD, n = 16 healthy controls, HCs). Plasma PFAS levels showed a significant inverse association with the age of CD diagnosis in infants who later progressed to the disease. Associations between BAs and triacylglycerols (TGs) showed different patterns already at birth in CD progressors, indicative of different absorption of lipids in these infants. In conclusion, PFAS exposure may modulate lipid and BA metabolism, and the impact is different in the infants who develop CD later in life, in comparison to HCs. The results indicate more efficient uptake of PFAS in such infants. Higher PFAS exposure during prenatal and early life may accelerate the progression to CD in the genetically predisposed children.

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Series: Environmental research
ISSN: 0013-9351
ISSN-E: 1096-0953
ISSN-L: 0013-9351
Volume: 188
Article number: 109864
DOI: 10.1016/j.envres.2020.109864
Type of Publication: A1 Journal article – refereed
Field of Science: 3142 Public health care science, environmental and occupational health
Funding: This study was supported by funding from Vetenskapsrådet (to T.H.; grant no. 2016–05176) and Formas (to T.H. and M.O.; grant no. 2019–00869). The DIPP study was supported by the following grants: JDRF (grants 1-SRA-2016-342-M-R, 1SRA-2019-732-M-B); European Union (grant BMH4-CT98-3314); Novo Nordisk Foundation; Academy of Finland (Decision No 292538 and Center of Excellence in Molecular Systems Immunology and Physiology Research, 2012–2017, Decision No. 250114) and Special Research Funds for University Hospitals in Finland. The funding sources had no role in study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the article for publication.
Copyright information: © 2020 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY license (