Lundregan, SL, Niskanen, AK, Muff, S, et al. Resistance to gapeworm parasite has both additive and dominant genetic components in house sparrows, with evolutionary consequences for ability to respond to parasite challenge. Mol Ecol. 2020; 29: 3812– 3829. https://doi.org/10.1111/mec.15491
Resistance to gapeworm parasite has both additive and dominant genetic components in house sparrows, with evolutionary consequences for ability to respond to parasite challenge
|Author:||Lundregan, Sarah L.1; Niskanen, Alina K.1,2; Muff, Stefanie3;|
1Centre for Biodiversity Dynamics, Department of Biology, Norwegian University of Science and Technology, Trondheim, Norway
2Ecology and Genetics Research Unit, University of Oulu, Oulu, Finland
3Centre for Biodiversity Dynamics, Department of Mathematical Sciences, Norwegian University of Science and Technology, Trondheim, Norway
4Evolutionary Biology, Department of Ecology and Genetics, Uppsala University, Uppsala, Sweden
|Online Access:||PDF Full Text (PDF, 1.4 MB)|
|Persistent link:|| http://urn.fi/urn:nbn:fi-fe2020110589349
John Wiley & Sons,
|Publish Date:|| 2020-11-05
Host–parasite relationships are likely to change over the coming decades in response to climate change and increased anthropogenic stressors. Understanding the genetic architecture of parasite resistance will aid prediction of species’ responses to intensified parasite challenge. The gapeworm “Syngamus trachea” is prevalent in natural bird populations and causes symptomatic infections ranging from mild to severe. The parasite may affect ecological processes by curtailing bird populations and is important due to its propensity to spread to commercially farmed birds. Our large‐scale data set on an insular house sparrow metapopulation in northern Norway includes information on gapeworm prevalence and infection intensity, allowing assessment of the genetics of parasite resistance in a natural system. To determine whether parasite resistance has a heritable genetic component, we performed variance component analyses using animal models. Resistance to gapeworm had substantial additive genetic and dominance variance, and genome‐wide association studies to identify single nucleotide polymorphisms associated with gapeworm resistance yielded multiple loci linked to immune function. Together with genome partitioning results, this indicates that resistance to gapeworm is under polygenic control in the house sparrow, and probably in other bird species. Hence, our results provide the foundation needed to study any eco‐evolutionary processes related to gapeworm infection, and show that it is necessary to use methods suitable for polygenic and nonadditive genetic effects on the phenotype.
|Pages:||3812 - 3829|
|Type of Publication:||
A1 Journal article – refereed
|Field of Science:||
1181 Ecology, evolutionary biology
This study was funded by the Research Council of Norway (RCN grant nos. 214553, 221956, 274930 and 302619), the RCN's Centres of Excellence funding scheme (grant no. 223257), the Academy of Finland (grant no. 295204 to A.K.N.), and the Norwegian University of Science and Technology.
|Academy of Finland Grant Number:||
295204 (Academy of Finland Funding decision)
© 2020 The Authors. Molecular Ecology published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.