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Gennadii A. Piavchenko, Evgeniya S. Seryogina, Ksenia Yu. Kandurova, Valery V. Shupletsov, Igor O. Kozlov, Dmitry D. Stavtsev, Olga A. Stelmashchuk, Evgeny A. Zherebtsov, Viktor V. Dremin, Aleksander G. Alekseyev M.D., Sergey L. Kuznetsov M.D., Andrey V. Dunaev, and Igor V. Meglinski "Brain metabolism changes in cases of impaired breathing or blood circulation in rodents evaluated by real time optical spectroscopy methods", Proc. SPIE 11234, Optical Biopsy XVIII: Toward Real-Time Spectroscopic Imaging and Diagnosis, 112341E (21 February 2020); https://doi.org/10.1117/12.2545708

Brain metabolism changes in cases of impaired breathing or blood circulation in rodents evaluated by real time optical spectroscopy methods

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Author: Piavchenko, Gennadii A.1,2; Seryogina, Evgeniya S.2; Kandurova, Ksenia Yu.2;
Organizations: 1Histology, Cytology and Embryology Department, I.M. Sechenov First Moscow State Medical University, Moscow, 119991, Russia
2R&D Center of Biomedical Photonics, Orel State University named after I.S. Turgenev, Komsomolskaya str. 95, Orel, 302026, Russia
3Opto-Electronics and Measurement Techniques Unit, Faculty of Information and Electrical Engineering, University of Oulu, 90570, Finland
4Anatomy, Operative Surgery and Emergency Medicine Department, Orel State University named after I.S. Turgenev, Oktyabrskaya str. 25, Orel, 302028, Russia
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 0.7 MB)
Persistent link: http://urn.fi/urn:nbn:fi-fe2020111089856
Language: English
Published: SPIE, 2020
Publish Date: 2020-11-10
Description:

Abstract

The aim of the study was to compare the metabolic activity of brain cortex after the acute hypoxia caused by the impairment of breathing or blood circulation. Male Wistar rats were randomized in two groups: impaired breathing and blood circulation failure groups. Fluorescence under 365 and 450 nm excitation and diffuse reflectance intensity at 550–820 nm range were estimated. We found that after long-term hypoxic conditions, notable metabolic changes occur. We suppose that oxygen deficiency causes an activation of the GABA shunt mechanism. In cases of blood circulation failure, fluorescence intensity changes faster than in cases of breathing impairment.

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Series: Progress in biomedical optics and imaging
ISSN: 1605-7422
ISSN-E: 2410-9045
ISSN-L: 1605-7422
ISBN: 978-1-5106-3232-5
ISBN Print: 978-1-5106-3231-8
Article number: 1E
DOI: 10.1117/12.2545708
OADOI: https://oadoi.org/10.1117/12.2545708
Host publication: Optical Biopsy XVIII: Toward Real-Time Spectroscopic Imaging and Diagnosis. 1-6 Feb 2020, SanFrancisco, USA
Host publication editor: Alfano, Robert R.
Demos, Stavros G.
Seddon, Angela B.
Conference: SPIE Bios
Type of Publication: B3 Article in conference proceedings
Field of Science: 114 Physical sciences
Subjects:
FAD
NADH
brain metabolism
diffuse reflectance spectra
fluorescence spectroscopy
laser speckle contrast imaging
neuronal hypoxia
resuscitation procedures
Article
Funding: This study was supported by the Russian Science Foundation under project No.18-15-00201. E.Z. acknowledges funding from the grant of the Academy of Finland (grant No. 318281), A.D. and I.M. acknowledge funding from the Academy of Finland (grant No. 326204). G.P. acknowledges Dr. Konstantin N. Lapin for catheterization guiding and useful discussion.
Academy of Finland Grant Number: 318281
326204
Detailed Information: 318281 (Academy of Finland Funding decision)
326204 (Academy of Finland Funding decision)
Copyright information: © (2020) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.