Optical fine needle biopsy in hepatocellular carcinoma mouse model

Potapova, Elena; Kandurova, Ksenia; Shupletsov, Valery; Seryogina, Evgeniya; Dremin, Viktor; Zherebtsov, Evgeny; Alekseyev, Alexander; Mamoshin, Andrian; Ivanov, Yuri; Panchenkov, Dmitry; Dunaev, Andrey

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	Elena Potapova, Ksenia Kandurova, Valery Shupletsov, Evgeniya Seryogina, Viktor Dremin, Evgeny Zherebtsov, Alexander Alekseyev, Andrian Mamoshin, Yuri Ivanov, Dmitry Panchenkov, and Andrey Dunaev "Optical fine needle biopsy in hepatocellular carcinoma mouse model", Proc. SPIE 11363, Tissue Optics and Photonics, 113630V (2 April 2020); https://doi.org/10.1117/12.2555154 Optical fine needle biopsy in hepatocellular carcinoma mouse model Saved in:
Author:	Potapova, Elena¹; Kandurova, Ksenia¹; Shupletsov, Valery¹; Seryogina, Evgeniya¹; Dremin, Viktor^1,2; Zherebtsov, Evgeny^1,2; Alekseyev, Alexander³; Mamoshin, Andrian^1,4; Ivanov, Yuri^5,6; Panchenkov, Dmitry⁷; Dunaev, Andrey¹
Organizations:	¹Research and Development Center of Biomedical Photonics, Orel State University, Russia ²Optoelectronics and Measurement Techniques Unit, University of Oulu, Finland ³Department of Anatomy, Operative Surgery and Emergency Medicine, Orel State University, Russia ⁴Orel Regional Clinical Hospital, Russia ⁵Federal Scientific and Clinical Center for Specialized Medical Service and Medical Technologies, Russia ⁶Central Research Institute of Tuberculosis, Russia ⁷A.I. Yevdokimov Moscow State University of Medicine and Dentistry, Russia
Format:	article
Version:	published version
Access:	open
Online Access:	PDF Full Text (PDF, 0.6 MB)
Persistent link:	http://urn.fi/urn:nbn:fi-fe2020111189899
Language:	English
Published:	SPIE, 2020
Publish Date:	2020-11-11
Description:	Abstract The paper describes the results of experimental studies using custom developed optical biopsy system for diagnostics in vivo during the procedure of fine needle aspiration biopsy. Experimental studies were conducted in laboratory mice with inoculated hepatocellular carcinoma. The measurements were carried out using fluorescence spectroscopy and diffuse reflectance spectroscopy methods to reveal metabolic and morphological changes in tissues. The results show that the developed approach is sensitive for cancer detection. Quantified differences in the maximum of fluorescence spectra and diffuse reflectance spectra between tumor and normal tissues were demonstrated and approved with morphological analysis. see all 
Series:	Proceedings of SPIE
ISSN:	0277-786X
ISSN-E:	1996-756X
ISSN-L:	0277-786X
Pages:	1 - 6
Article number:	113630V
DOI:	10.1117/12.2555154
OADOI:	https://oadoi.org/10.1117/12.2555154
Host publication:	Proceedings Volume 11363, Tissue Optics and Photonics
Host publication editor:	Tuchin, Valery V. Blondel, Walter C. P. M. Zalevsky, Zeev
Conference:	SPIE Photonics Europe
Type of Publication:	B3 Article in conference proceedings
Field of Science:	217 Medical engineering
Subjects:	diffuse reflectance spectroscopy fine needle aspiration biopsy fluorescence spectroscopy hepatocellular carcinoma liver cancer optical biopsy Article
Funding:	This study was supported by the Russian Science Foundation under project № 18-15-00201. Authors are very grateful to Dr. Olga V. Morozova (N.N. Blokhin Russian Cancer Research Center, Moscow, Russia) for tumor cell inoculation.
Copyright information:	© (2020) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.

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Optical fine needle biopsy in hepatocellular carcinoma mouse model

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