University of Oulu

Elena Potapova, Ksenia Kandurova, Valery Shupletsov, Evgeniya Seryogina, Viktor Dremin, Evgeny Zherebtsov, Alexander Alekseyev, Andrian Mamoshin, Yuri Ivanov, Dmitry Panchenkov, and Andrey Dunaev "Optical fine needle biopsy in hepatocellular carcinoma mouse model", Proc. SPIE 11363, Tissue Optics and Photonics, 113630V (2 April 2020);

Optical fine needle biopsy in hepatocellular carcinoma mouse model

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Author: Potapova, Elena1; Kandurova, Ksenia1; Shupletsov, Valery1;
Organizations: 1Research and Development Center of Biomedical Photonics, Orel State University, Russia
2Optoelectronics and Measurement Techniques Unit, University of Oulu, Finland
3Department of Anatomy, Operative Surgery and Emergency Medicine, Orel State University, Russia
4Orel Regional Clinical Hospital, Russia
5Federal Scientific and Clinical Center for Specialized Medical Service and Medical Technologies, Russia
6Central Research Institute of Tuberculosis, Russia
7A.I. Yevdokimov Moscow State University of Medicine and Dentistry, Russia
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 0.6 MB)
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Language: English
Published: SPIE, 2020
Publish Date: 2020-11-11


The paper describes the results of experimental studies using custom developed optical biopsy system for diagnostics in vivo during the procedure of fine needle aspiration biopsy. Experimental studies were conducted in laboratory mice with inoculated hepatocellular carcinoma. The measurements were carried out using fluorescence spectroscopy and diffuse reflectance spectroscopy methods to reveal metabolic and morphological changes in tissues. The results show that the developed approach is sensitive for cancer detection. Quantified differences in the maximum of fluorescence spectra and diffuse reflectance spectra between tumor and normal tissues were demonstrated and approved with morphological analysis.

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Series: Proceedings of SPIE
ISSN: 0277-786X
ISSN-E: 1996-756X
ISSN-L: 0277-786X
Pages: 1 - 6
Article number: 113630V
DOI: 10.1117/12.2555154
Host publication: Proceedings Volume 11363, Tissue Optics and Photonics
Host publication editor: Tuchin, Valery V.
Blondel, Walter C. P. M.
Zalevsky, Zeev
Conference: SPIE Photonics Europe
Type of Publication: B3 Article in conference proceedings
Field of Science: 217 Medical engineering
Funding: This study was supported by the Russian Science Foundation under project № 18-15-00201. Authors are very grateful to Dr. Olga V. Morozova (N.N. Blokhin Russian Cancer Research Center, Moscow, Russia) for tumor cell inoculation.
Copyright information: © (2020) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.