University of Oulu

Igor Kozlov, Evgeny Zherebtsov, Angelina Zherebtsova, Yulia Loktionova, Elena Zharkikh, and Andrey Dunaev "Time-frequency analysis and laser Doppler spectrum decomposition to reveal new feature space for diagnosis of diabetes mellitus vascular complications", Proc. SPIE 11363, Tissue Optics and Photonics, 113631I (6 April 2020);

Time-frequency analysis and laser Doppler spectrum decomposition to reveal new feature space for diagnosis of diabetes mellitus vascular complications

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Author: Kozlov, Igor1; Zherebtsov, Evgeny1,2; Zherebtsova, Angelina1;
Organizations: 1Orel State University named after I.S. Turgenev, Komsomolskaya St. 95, Orel, Russia
2Optoelectronics and Measurement Techniques, University of Oulu, Oulu, FI-90014, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 1.5 MB)
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Language: English
Published: SPIE, 2020
Publish Date: 2020-11-11


Early diagnostics of microcirculation complications is an important area for biomedical photonics application. The blood perfusion measurements are capable of identification of particular markers for diagnostics of many pathological conditions of blood microcirculation in the skin. In this work, we apply the laser Doppler flowmetry method with the ability to record and process the power spectra of registered photocurrent. This approach provides the estimation of signal amplitude distribution along with the frequencies of Doppler-broadened laser radiation and blood perfusion distribution. In this work, we investigate the blood ow in the skin by the time- frequency analysis of the recorded laser Doppler spectra. The conducted studies allowed us to propose new diagnostic criteria for the diagnosis of diabetes mellitus type 2 complications. The diagnostic parameters have been tested together with binary classifiers based on the linear discriminant analysis and demonstrated to be able to successfully distinguish the groups of volunteers of different age and patients with microvascular complications.

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Series: Proceedings of SPIE
ISSN: 0277-786X
ISSN-E: 1996-756X
ISSN-L: 0277-786X
Article number: 113631I
DOI: 10.1117/12.2557035
Host publication: Proceedings Volume 11363, Tissue Optics and Photonics
Host publication editor: Tuchin, Valery V.
Blondel, Walter C. P. M.
Zalevsky, Zeev
Conference: SPIE Photonics Europe
Type of Publication: B3 Article in conference proceedings
Field of Science: 217 Medical engineering
Funding: I. Kozlov and A. Dunaev (data analysis, protocol design and manuscript drafting) kindly regards RFBR for funding project number 19-31-27001. A. Zherebtsova and E. Zharkikh (data acquisition) acknowledge the support of the Russian Science Foundation (the research project 18-79-00237). E. Zherebtsov (designed the study and experimental setup, conducted data processing) acknowledges the support of the Academy of Finland, grant 318281.
Academy of Finland Grant Number: 318281
Detailed Information: 318281 (Academy of Finland Funding decision)
Copyright information: © (2020) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.