University of Oulu

Sauna‐aho, O, Bjelogrlic‐Laakso, N, Rautava, P, Arvio, M. Ageing and cognition in men with fragile X syndrome. J Appl Res Intellect Disabil. 2020; 33: 1113– 1118.

Ageing and cognition in men with fragile X syndrome

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Author: Sauna‐aho, Oili1,2; Bjelogrlic‐Laakso, Nina3; Rautava, Päivi2;
Organizations: 1KTO‐Special Welfare District of Varsinais‐Suomi, Paimio, Finland
2Public Health, Turku University Hospital, Turku University, Turku, Finland
3Tampere University Hospital, Special Welfare District of Pirkanmaa, Tampere, Finland
4Clinical Genetics, Turku University Hospital, Turku, Finland
5Neurology, Päijät‐Häme Joint Municipal Authority, Lahti, Finland
6PEDEGO, University of Oulu, Oulu, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 0.4 MB)
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Language: English
Published: John Wiley & Sons, 2020
Publish Date: 2020-11-11


Background: Fragile X syndrome (FXS) is the most common inherited cause of intellectual disability. The aim of our longitudinal study was to describe ageing‐related cognitive changes in men with FXS.

Method: A neuropsychologist determined the raw scores (RSs) of 19 men with FXS twice with the Leiter International Performance Scale at an average interval of 22 years. The ages of the participants at baseline ranged from 16 to 50 (mean 27) years.

Results: At follow‐up, the RSs improved in two men, remained the same in two men and declined in 15 men. Overall, the RS of the study group deteriorated by an average 4 points in RSs (p < 0.001).

Conclusion: Cognitive ageing in men with FXS started earlier than that in men in the general population; in many cases, cognitive ageing in men with FXS began before middle age, usually without any medical or other underlying cause.

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Series: Journal of applied research in intellectual disabilities
ISSN: 1360-2322
ISSN-E: 1468-3148
ISSN-L: 1360-2322
Volume: 33
Issue: 5
Pages: 1113 - 1118
DOI: 10.1111/jar.12733
Type of Publication: A1 Journal article – refereed
Field of Science: 3111 Biomedicine
3112 Neurosciences
Funding: The funding received from the Päijät‐Häme Cultural Foundation, Finland and Turku University Hospital, was essential for the completion of this study.
Copyright information: © 2020 The Authors. Journal of Applied Research in Intellectual Disabilities published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.