University of Oulu

Stephen, R., Solomon, A., Ngandu, T., Levälahti, E., Rinne, J. O., Kemppainen, N., Parkkola, R., Antikainen, R., Strandberg, T., Kivipelto, M., Soininen, H., Liu, Y., & for the FINGER study group. (2020). White Matter Changes on Diffusion Tensor Imaging in the FINGER Randomized Controlled Trial [JB]. Journal of Alzheimer’s Disease, 78(1), 75–86.

White matter changes on diffusion tensor imaging in the FINGER randomized controlled trial

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Author: Stephen, Ruth1; Solomon, Alina1,2; Ngandu, Tiia2,3;
Organizations: 1Institute of Clinical Medicine/Neurology, University of Eastern Finland, Kuopio, Finland
2Division of Clinical Geriatrics, Center for Alzheimer Research, NVS, Karolinska Institutet, Stockholm, Sweden
3Public Health Promotion Unit, Finnish Institute for Health and Welfare, Helsinki, Finland
4Division of Clinical Neurosciences, Turku University Hospital, Turku, Finland
5Turku PET Centre, University of Turku, Turku, Finland
6Center for Life Course Health Research/Geriatrics, University of Oulu, Oulu, Finland
7Medical Research Center Oulu, Oulu University Hospital and Oulu City Hospital, Oulu, Finland
8Department of Medicine, Geriatric Clinic, University of Helsinki, Helsinki University Central Hospital, Helsinki, Finland
9Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland
10Ageing Epidemiology (AGE) Research Unit, School of Public Health, Imperial College London, London, United Kingdom
11Neurocenter, Neurology, Kuopio University Hospital, Kuopio, Finland
12Department of Clinical Radiology, Kuopio University Hospital, Kuopio, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 2.5 MB)
Persistent link:
Language: English
Published: IOS Press, 2020
Publish Date: 2020-11-24


Background: Early pathological changes in white matter microstructure can be studied using the diffusion tensor imaging (DTI). It is not only important to study these subtle pathological changes leading to cognitive decline, but also to ascertain how an intervention would impact the white matter microstructure and cognition in persons at-risk of dementia.

Objectives: To study the impact of a multidomain lifestyle intervention on white matter and cognitive changes during the 2-year Finnish Geriatric Intervention Study to prevent Cognitive Impairment and Disability (FINGER), a randomized controlled trial in at-risk older individuals (age 60–77 years) from the general population.

Methods: This exploratory study consisted of a subsample of 60 FINGER participants. Participants were randomized to either a multidomain intervention (diet, exercise, cognitive training, and vascular risk management, n = 34) or control group (general health advice, n = 26). All underwent baseline and 2-year brain DTI. Changes in fractional anisotropy (FA), diffusivity along domain (F1) and non-domain (F2) diffusion orientations, mean diffusivity (MD), axial diffusivity (AxD), radial diffusivity (RD), and their correlations with cognitive changes during the 2-year multidomain intervention were analyzed.

Results: FA decreased, and cognition improved more in the intervention group compared to the control group (p < 0.05), with no significant intergroup differences for changes in F1, F2, MD, AxD, or RD. The cognitive changes were significantly positively related to FA change, and negatively related to RD change in the control group, but not in the intervention group.

Conclusion: The 2-year multidomain FINGER intervention may modulate white matter microstructural alterations.

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Series: Journal of Alzheimer's disease
ISSN: 1387-2877
ISSN-E: 1875-8908
ISSN-L: 1387-2877
Volume: 78
Issue: 1
Pages: 75 - 86
DOI: 10.3233/JAD-200423
Type of Publication: A1 Journal article – refereed
Field of Science: 3121 General medicine, internal medicine and other clinical medicine
Funding: This study was supported by funding from Academy of Finland, European Research Council grant 804371; Finnish Social Insurance Institution, Alzheimer’s Research and Prevention Foundation, Juho Vainio Foundation, EVO/VTR grants of University Hospitals of Kuopio, Oulu and Turku, Seinäjoki Central hospital and Oulu City Hospital; MIND-AD and EURO-FINGERS Joint Programme - Neurodegenerative Disease Research (JPND); Center for Innovative Medicine (CIMED) at Karolinska Institutet Sweden; Stiftelsen Stockholms sjukhem Sweden; Knut and Alice Wallenberg Foundation (Sweden); Konung Gustaf V:s och Drottning Victorias Frimurarstiftelse Sweden; Alzheimerfonden Sweden; Swedish Research Council; Region Stockholm ALF and NSV grants.
Copyright information: © 2020 – IOS Press and the authors. All rights reserved. This article is published online with Open Access and distributed under the terms of the Creative Commons Attribution Non-Commercial License (CC BY-NC 4.0).