University of Oulu

Teemu Myllylä, Priya Karthikeyan, Ulriika Honka, Vesa Korhonen, Sakari S. Karhula, Juha Nikkinen, "Cerebral haemodynamic effects in the human brain during radiation therapy for brain cancer," Proc. SPIE 11363, Tissue Optics and Photonics, 1136307 (2 April 2020); doi: 10.1117/12.2555892

Cerebral haemodynamic effects in the human brain during radiation therapy for brain cancer

Saved in:
Author: Myllylä, Teemu1,2; Karthikeyan, Priya1; Honka, Ulriika1;
Organizations: 1University of Oulu, Research Unit of Medical Imaging, Physics and Technology, Oulu, Finland
2University of Oulu, Optoelectronics and Measurement Techniques Unit, Oulu, Finland
3Oulu University Hospital, Department of Diagnostic Radiology, Oulu, Finland
4Medical Research Center (MRC), Oulu, Finland
5Oulu University Hospital, Department of Oncology and Radiotherapy, Oulu, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 0.6 MB)
Persistent link:
Language: English
Published: SPIE, 2020
Publish Date: 2020-11-25


Radiotherapy is already well-established and an effective form of treatment for many cancers, especially for brain tumors. Currently, the clinical efficacy of a treatment, however, can only be established based on clinical or radiological responses observed after a significant period of time following the single irradiations during radiotherapy course. On the other hand, the radiotherapy dose is limited by its toxicity to surrounding healthy tissues. Particularly, radiation to brain tumors may sub-acutely or chronically affect cognition and cause fatigue even with conventional doses. However, there is currently no on-line and safe method to monitor the effects of radiation to the brain during the irradiation. In our project, we aim to develop an on-line method to monitor effects in brain tissue that correlate with the radiation dose in radiotherapy. In this case study, we use functional near-infrared spectroscopy (fNIRS) and study possible temporal effects in cerebral haemodynamics during irradiations of whole-brain radiotherapy (WBRT). fNIRS is safe for the patient, it can be used noninvasively and also in demanding environments, such as in radiotherapy treatment rooms during irradiation, and thus could be in future potential technique to be utilized for monitoring tailored radiotherapy.

see all

Series: Proceedings of SPIE
ISSN: 0277-786X
ISSN-E: 1996-756X
ISSN-L: 0277-786X
ISBN Print: 978-1-5106-3498-5
Article number: 1136307
DOI: 10.1117/12.2555892
Host publication: Proceedings Volume 11363, Tissue Optics and Photonic. SPIE Photonics Europe, 2020
Host publication editor: Tuchin, V. V.
Blondel, W. C. P. M.
Zalevsky, Z.
Conference: SPIE Photonics Europe
Type of Publication: B3 Article in conference proceedings
Field of Science: 3126 Surgery, anesthesiology, intensive care, radiology
3122 Cancers
Funding: This work was supported by Academy of Finland (grant 318347) and EDUFI Fellowships (P.K.).
Academy of Finland Grant Number: 318347
Detailed Information: 318347 (Academy of Finland Funding decision)
Copyright information: © 2020 SPIE. The Definitive Version of Record can be found online: