University of Oulu

Musammir Khan, Fawad Ahmad, Janne T. Koivisto, Minna Kellomäki, Green synthesis of controlled size gold and silver nanoparticles using antioxidant as capping and reducing agent, Colloid and Interface Science Communications, Volume 39, 2020, 100322, ISSN 2215-0382,

Green synthesis of controlled size gold and silver nanoparticles using antioxidant as capping and reducing agent

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Author: Khan, Musammir1; Ahmad, Fawad1; Koivisto, Janne T.2,3;
Organizations: 1Department of Chemistry, University of Wah, Quaid Avenue, Wah Cantt., Rawalpindi, Punjab, Pakistan
2Biomaterials and Tissue Engineering Group, BioMediTech Institute, Faculty of Medicine and Health Technology, Tampere University, Korkeakoulunkatu 10, 33720 Tampere, Finland
3Microelectronics Research Unit, Faculty of Information Technology and Electrical Engineering, University of Oulu, PL 4500, 90570 Oulu, Finland
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 3 MB)
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Language: English
Published: Elsevier, 2020
Publish Date: 2020-11-30


Here silver (GA-AgNPs) and gold nanoparticles (GA-AuNPs) were synthesized by an ecofriendly method using antioxidant, gallic acid (GA) simultaneously as capping and reducing agent. Their size ranged between 15 nm and 80 nm, which was controlled or dependent on the feeding ratio of GA. There was a linear relationship between the particle sizes versus the GA content. Moreover, they indicated a negative zeta potential value, which was decreased from −33 mV to −40 mV for AgNPs and from −36 mV to −42 mV for AuNPs after the addition of GA. In a typical PEGylation reaction of them, resulted into a large increase in the particle size as well as zeta potential value. The cytotoxicity assay against human fibroblast cell line (WI-38) for 24 h and 3-days showed that they were completely safe toward these cells. Therefore, these engineered NPs could be considered promising supplementary targeting materials in future.

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Series: Colloids and interface science communications
ISSN: 2215-0382
ISSN-L: 2215-0382
Volume: 39
Article number: 100322
DOI: 10.1016/j.colcom.2020.100322
Type of Publication: A1 Journal article – refereed
Field of Science: 216 Materials engineering
1182 Biochemistry, cell and molecular biology
116 Chemical sciences
Funding: The authors acknowledge Tampere University of Technology (internal funding for postdoctoral researchers) and TEKES Finnish Funding Agency for Innovation project Human Spare Parts for financially supporting this work.
Copyright information: © 2020 Elsevier B.V. This is an open access article under the CC BY-NC-ND license (