University of Oulu

Billot, M., Calvani, R., Urtamo, A., Sánchez-Sánchez, J., Ciccolari-Micaldi, C., Chang, M., Roller-Wirnsberger, R., Wirnsberger, G., Sinclair, A., Vaquero-Pinto, M., Jyväkorpi, S., Öhman, H., Strandberg, T., Schols, J., Schols, A., Smeets, N., Topinkova, E., Michalkova, H., Bonfigli, A., Lattanzio, F., Rodríguez-Mañas, L., Coelho, H., Broccatelli, M., D’Elia, M., Biscotti, D., Marzetti, E., Freiberger, E. (2020), Preserving Mobility in Older Adults with Physical Frailty and Sarcopenia: Opportunities, Challenges, and Recommendations for Physical Activity Interventions. Clinical interventions in Aging, Volume 15, 1675-1690.

Preserving mobility in older adults with physical frailty and sarcopenia : opportunities, challenges, and recommendations for physical activity interventions

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Author: Billot, Maxime1,2; Calvani, Riccardo3,4; Urtamo, Annele5;
Organizations: 1Clinical Gerontology, University Hospital of Limoges, Limoges, France
2PRISMATICS (Predictive Research in Spine/Neurostimulation Management and Thoracic Innovation in Cardiac Surgery), Poitiers University Hospital, Poitiers, France
3Università Cattolica del Sacro Cuore, Rome, Italy
4Fondazione Policlinico Universitario "Agostino Gemelli" IRCCS, Rome, Italy
5University of Helsinki, Department of General Practice and Primary Health Care, Helsinki University Central Hospital, Unit of Primary Health Care, Helsinki, Finland
6Foundation for Biomedical Research Getafe University Hospital, Madrid, Spain
7Faculty of Health Promotion, Sports and Leisure Studies, School of Education, University of Iceland, Reykjavik, Iceland
8The Icelandic Gerontological Research Center, Landspitali University Hospital and University of Iceland, Reykjavik, Iceland
9Medical University of Graz, Department of Internal Medicine, Graz, Austria
10Medical University of Graz, Division of Nephrology, Department of Internal Medicine, Graz, Austria
11Foundation for Diabetes Research in Older People, Diabetes Frail Ltd., Luton, UK
12University Hospital of Ramon Cajal IRYCIS, Madrid, Spain
13University of Helsinki, Clinicum, Helsinki, Finland; Helsinki University Hospital, Medicine and Rehabilitation, Helsinki, Finland
14University of Oulu, Center for Life Course Health Research, Oulu, Finland
15Department of Health Services Research, Maastricht University Medical Center, Maastricht, The Netherlands
16Department of Respiratory Medicine, School of Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University Medical Center, Maastricht, The Netherlands
17Department of Health & Fitness, Maastricht University Medical Center, Maastricht, The Netherlands
18First Faculty of Medicine, Charles University, Prague, Czech Republic
19Faculty of Social and Health Sciences, South Bohemian University, Ceske Budejovice, Czech Republic
20Scientific Direction, IRCCS INRCA, Ancona, Italy
21Geriatrics Service, University Hospital of Getafe, Madrid, Spain
22Institute for Biomedicine of Aging, FAU Erlangen-Nürnberg, Nürnberg, Germany
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 1.7 MB)
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Language: English
Published: Dove Medical Press, 2020
Publish Date: 2020-12-03


One of the most widely conserved hallmarks of aging is a decline in functional capabilities. Mobility loss is particularly burdensome due to its association with negative health outcomes, loss of independence and disability, and the heavy impact on quality of life. Recently, a new condition, physical frailty and sarcopenia, has been proposed to define a critical stage in the disabling cascade. Physical frailty and sarcopenia are characterized by weakness, slowness, and reduced muscle mass, yet with preserved ability to move independently. One of the strategies that have shown some benefits in combatting mobility loss and its consequences for older adults is physical activity. Here, we describe the opportunities and challenges for the development of physical activity interventions in people with physical frailty and sarcopenia. The aim of this article is to review age-related physio(patho)logical changes that impact mobility in old age and to provide recommendations and procedures in accordance with the available literature.

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Series: Clinical interventions in aging
ISSN: 1176-9092
ISSN-E: 1178-1998
ISSN-L: 1176-9092
Issue: 15
Pages: 1675 - 1690
DOI: 10.2147/CIA.S253535
Type of Publication: A2 Review article in a scientific journal
Field of Science: 3121 General medicine, internal medicine and other clinical medicine
Funding: The present work was funded by a grant from the Innovative Medicines Initiative—Joint Undertaking (IMI-JU 115621). The work was also partially supported by the nonprofit research foundation “Centro Studi Achille e Linda Lorenzon” and by intramural research grants from the Università Cattolica del Sacro Cuore (D3.2 2013 and D3.2 2015).
Copyright information: © 2020 Billot et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.