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Diabetes is associated with familial idiopathic normal pressure hydrocephalus : a case–control comparison with family members |
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| Author: | Räsänen, Joel1,2; Huovinen, Joel1,2; Korhonen, Ville E.1,2; |
| Organizations: |
1Department of Neurosurgery, Kuopio University Hospital, P.O.Box 100, 70029, Kuopio, KYS, Finland 2Institute of Clinical Medicine-Neurosurgery, University of Eastern Finland, Kuopio, Finland 3Department of Neurosurgery, University of Helsinki, Helsinki, Finland
4Department of Neurosurgery, Helsinki University Hospital, Helsinki, Finland
5Clinical Neurosciences, Department of Neurosurgery, University of Turku, Turku, Finland 6Department of Neurosurgery, Turku University Hospital, Turku, Finland 7Department of Neurosurgery, Tampere University Hospital, Tampere, Finland 8Unit of Clinical Neuroscience, Neurosurgery, University of Oulu and Medical Research Center, Oulu University Hospital, Oulu, Finland 9National Institute for Health and Welfare, Helsinki, Finland 10University of Helsinki, Helsinki, Finland 11Institute of Clinical Medicine–Neurology, University of Eastern Finland, Kuopio, Finland 12Unit of Clinical Neuroscience, Neurology, University of Oulu, Oulu, Finland 13Medical Research Center, Oulu University Hospital, Oulu, Finland 14Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland 15Analytical and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital, Boston, USA 16Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, USA 17Stanley Center for Psychiatric Research, Broad Institute for Harvard and MIT, Cambridge, USA |
| Format: | article |
| Version: | published version |
| Access: | open |
| Online Access: | PDF Full Text (PDF, 1.2 MB) |
| Persistent link: | http://urn.fi/urn:nbn:fi-fe2020120499447 |
| Language: | English |
| Published: |
Springer Nature,
2020
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| Publish Date: | 2020-12-04 |
| Description: |
AbstractBackground: The pathophysiological basis of idiopathic normal pressure hydrocephalus (iNPH) is still unclear. Previous studies have shown a familial aggregation and a potential heritability when it comes to iNPH. Our aim was to conduct a novel case-controlled comparison between familial iNPH (fNPH) patients and their elderly relatives, involving multiple different families. Methods: Questionnaires and phone interviews were used for collecting the data and categorising the iNPH patients into the familial (fNPH) and the sporadic groups. Identical questionnaires were sent to the relatives of the potential fNPH patients. Venous blood samples were collected for genetic studies. The disease histories of the probable fNPH patients (n = 60) were compared with their ≥ 60-year-old relatives with no iNPH (n = 49). A modified Charlson Comorbidity Index (CCI) was used to measure the overall disease burden. Fisher’s exact test (two-tailed), the Mann–Whitney U test (two-tailed) and a multivariate binary logistic regression analysis were used to perform the statistical analyses. Results: Diabetes (32% vs. 14%, p = 0.043), arterial hypertension (65.0% vs. 43%, p = 0.033), cardiac insufficiency (16% vs. 2%, p = 0.020) and depressive symptoms (32% vs. 8%, p = 0.004) were overrepresented among the probable fNPH patients compared to their non-iNPH relatives. In the age-adjusted multivariate logistic regression analysis, diabetes remained independently associated with fNPH (OR = 3.8, 95% CI 1.1–12.9, p = 0.030). Conclusions: Diabetes is associated with fNPH and a possible risk factor for fNPH. Diabetes could contribute to the pathogenesis of iNPH/fNPH, which motivates to further prospective and gene-environmental studies to decipher the disease modelling of iNPH/fNPH. see all
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| Series: |
Fluids and barriers of the CNS |
| ISSN: | 2045-8118 |
| ISSN-E: | 2045-8118 |
| ISSN-L: | 2045-8118 |
| Volume: | 17 |
| Issue: | 1 |
| Article number: | 57 |
| DOI: | 10.1186/s12987-020-00217-0 |
| OADOI: | https://oadoi.org/10.1186/s12987-020-00217-0 |
| Type of Publication: |
A1 Journal article – refereed |
| Field of Science: |
3124 Neurology and psychiatry 3112 Neurosciences |
| Subjects: | |
| Funding: |
This study was funded by the Finnish Medical Foundation, Academy of Finland (307866), EVO/VTR Grants 5252614 and 5772708 of Kuopio University Hospital, Sigrid Juselius Foundation, the Strategic Funding of the University of Eastern Finland (UEF-Brain), FP7, Grant Agreement No. 601055, VPH Dementia Research Enabled by IT VPH-DARE@IT and BIOMARKAPD project in the JPND Program. The funding sources had no involvement in the study design; the collection, the analysis and the interpretation of the data; in the writing of the report; and in the decision to submit the article for publication. |
| Copyright information: |
© The Author(s) 2020. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
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https://creativecommons.org/licenses/by/4.0/ |