University of Oulu

Motahareh Peyvasteh et al 2020 Laser Phys. Lett. 17 115606

3D Mueller-matrix-based azimuthal invariant tomography of polycrystalline structure within benign and malignant soft-tissue tumours

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Author: Peyvasteh, Motahareh1; Tryfonyuk, Liliya2; Ushenko, Vladimir3;
Organizations: 1Optoelectronics and Measurement Techniques Laboratory, University of Oulu, Oulu, Finland
2Department of Forensic Medicine, Bukovinian State Medical University, Chernivtsi, Ukraine
3Optics and Publishing Department, Chernivtsi National University, Chernivtsi, Ukraine
4Interdisciplinary Laboratory of Biophotonics, National Research Tomsk State University, Tomsk, Russia
5Institute of Engineering Physics for Biomedicine (PhysBio), National Research Nuclear University ‘MEPhI’, Moscow, Russia
6Department of Histology, Cytology and Embryology, Institute of Clinical Medicine N V Sklifosovsky, I M Sechenov First Moscow State Medical University, Moscow, Russia
7College of Engineering and Physical Sciences, Aston University, Birmingham, United Kingdom
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 1.6 MB)
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Language: English
Published: IOP Publishing, 2020
Publish Date: 2020-12-08


We introduce a method of azimuthally invariant 3D Mueller-matrix (MM) layer-by-layer mapping of the phase and amplitude parameters of anisotropy of the partially depolarizing layers of benign (adenoma) and malignant (carcinoma) prostate tumours. The technique is based on the analysis of spatial variations of Mueller matrix invariant (MMI) of histological sections of benign (adenoma) and malignant (carcinoma) tissue samples. The phase dependence of magnitudes of the first-to-fourth order statistical moments is applied to characterize 3D spatial distributions of MMI of linear and circular birefringence and dichroism of prostate tumours. The high order statistical moments and phase sections of the optimal differentiation of the polycrystalline structure of tissue samples are revealed. The obtained results are compared with the results obtained by conventional methods utilizing polarized light, including 2D and 3D Mueller matrix imaging.

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Series: Laser physics letters
ISSN: 1612-2011
ISSN-E: 1612-202X
ISSN-L: 1612-2011
Volume: 17
Issue: 11
Article number: 115606
DOI: 10.1088/1612-202X/abbee0
Type of Publication: A1 Journal article – refereed
Field of Science: 217 Medical engineering
213 Electronic, automation and communications engineering, electronics
114 Physical sciences
Funding: This project has received funding from the ATTRACT project funded by the EC under Grant Agreement 777222, Academy of Finland (Grant No. 325097), and INFOTECH strategic funding and National Research Foundation of Ukraine Fund Program. IM also acknowledges partial support from MEPhI Academic Excellence Project (Contract No. 02.a03.21.0005), Russian Science Foundation (Project 19-72-30012), the National Research Tomsk State University Academic D.I. Mendeleev Fund Program.
Academy of Finland Grant Number: 325097
Detailed Information: 325097 (Academy of Finland Funding decision)
Copyright information: © 2020 Astro Ltd. Original content from this work may be used under the terms of the Creative Commons Attribution 3.0 licence. Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI.