University of Oulu

Isohanni M, Miettunen J, Penttilä M. Life span development of schizophrenia: symptoms, clinical course and outcomes. In: Psychotic Disorders: Comprehensive Conceptualization and Treatments. Editors: Carol A. Tamminga, Elena I. Ivleva Ulrich Reininghaus, Jim van Os, (pp. 143-151). Oxford: Oxford University Press.

Life span development of schizophrenia : symptoms, clinical course, and outcomes

Saved in:
Author: Isohanni, Matti1; Miettunen, Jouko1; Penttilä, Matti1
Organizations: 1University of Oulu
Format: article
Version: accepted version
Access: open
Online Access: PDF Full Text (PDF, 0.3 MB)
Persistent link:
Language: English
Published: Oxford University Press, 2020
Publish Date: 2021-11-30


Schizophrenia is a common, often life-long disorder, beginning mostly in early adulthood. It has remarkably negative effects on personal, familial, somatic, and social well-being. Outcomes range from recovery to chronic disability. Subtle premorbid deviances in motor, cognitive, emotional, and behavioral domains exist. Continuous symptomatology, brain matter loss, cognitive deterioration, excess somatic comorbidity, and premature mortality are seen throughout the life span. The proportion achieving full recovery is small (13.5%) and appears to be stable over recent decades. Many aged individuals with schizophrenia have a favorable clinical and social course. A gap exists in the areas of health and adult creative potential between people with and without schizophrenia. We have an incomplete understanding of the disease mechanisms, lifelong natural course and of how to optimize care during the life span. Current evidence-based treatments have moderate effects and are used insufficiently.

see all

ISBN: 978-0-19-065329-3
ISBN Print: 978-0-19-065327-9
Pages: 143 - 151
DOI: 10.1093/med/9780190653279.003.001
Host publication: Psychotic disorders : comprehensive conceptualization and treatments
Host publication editor: Tamminga, Carol A.
van Os, Jim
Reininghaus, Ulrich
Ivleva, Elena
Type of Publication: A3 Book chapter
Field of Science: 3124 Neurology and psychiatry
Copyright information: © 2020 Oxford University Press. Reproduced by permission of Oxford University Press