University of Oulu

Tianmiao Zhang, Ravshanjon Nazarov, Alexey P. Popov, Petr S. Demchenko, Alexander V. Bykov, Roman O. Grigorev, Anna V. Kuzikova, Victoria Y. Soboleva, Dmitrii V. Zykov, Igor V. Meglinski, and Mikhail K. K. Khodzitskiy "Development of oral cancer tissue-mimicking phantom based on polyvinyl chloride plastisol and graphite for terahertz frequencies," Journal of Biomedical Optics 25(12), 123002 (17 November 2020).

Development of oral cancer tissue-mimicking phantom based on polyvinyl chloride plastisol and graphite for terahertz frequencies

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Author: Zhang, Tianmiao1,2; Nazarov, Ravshanjon1; Popov, Alexey P.3;
Organizations: 1ITMO University, School of Photonics, Terahertz Biomedicine Laboratory, Saint Petersburg, Russia
2Tydex LLC, Saint Petersburg, Russia
3University of Oulu, Faculty of Information Technology and Electrical Engineering, Optoelectronics and Measurement Techniques Laboratory, Oulu, Finland
4Aston University, Aston Institute of Materials Research, School of Engineering and Applied Science, Birmingham, United Kingdom
5Aston University, School of Life and Health Sciences, Birmingham, United Kingdom
Format: article
Version: published version
Access: open
Online Access: PDF Full Text (PDF, 22 MB)
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Language: English
Published: SPIE, 2020
Publish Date: 2020-12-15


Significance: A new concept of a biotissue phantom for terahertz (THz) biomedical applications is needed for reliable and long-term usage.

Aim: We aimed to develop a new type of biotissue phantom without water content and with controllable THz optical properties by applying graphite powders into a polyvinyl chloride plastisol (PVCP) matrix and to give a numerical description to the THz optical properties of the phantoms using the Bruggeman model (BM) of the effective medium theory (EMT).

Approach: The THz optical properties of graphite and the PVCP matrix were measured using THz time-domain spectroscopy, which works in the frequency range from 0.1 to 1 THz. Two phantoms with 10% and 12.5% graphite were fabricated to evaluate the feasibility of describing phantoms using the EMT. The EMT then was used to determine the concentration of graphite required to mimic the THz optical properties of human cancerous and healthy oral tissue.

Results: The phantom with 16.7% of graphite has the similar THz optical properties as human cancerous oral tissue in the frequency range of 0.2 to 0.7 THz. The THz optical properties of the phantom with 21.9% of graphite are close to those of human healthy oral tissue in the bandwidth from 0.6 to 0.8 THz. Both the refractive index and absorption coefficient of the samples increase with an increase of graphite concentration. The BM of the EMT was used as the numerical model to describe the THz optical properties of the phantoms. The relative error of the BM for the refractive index estimation and the absorption coefficient is up to 4% and 8%, respectively.

Conclusions: A water-free biotissue phantom that mimics the THz optical properties of human cancerous oral tissue was developed. With 21.9% of graphite, the phantom also mimics human healthy oral tissue in a narrow frequency range. The BM proved to be a suitable numerical model of the phantom.

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Series: Journal of biomedical optics
ISSN: 1083-3668
ISSN-E: 1560-2281
ISSN-L: 1083-3668
Volume: 25
Issue: 12
Article number: 123002
DOI: 10.1117/1.JBO.25.12.123002
Type of Publication: A1 Journal article – refereed
Field of Science: 114 Physical sciences
Funding: This work was financially supported by the Government of Russian Federation, Grant No. 08-08. AB and AP acknowledges the Academy of Finland (Grant Nos. 290596 and 314369).
Academy of Finland Grant Number: 290596
Detailed Information: 290596 (Academy of Finland Funding decision)
314369 (Academy of Finland Funding decision)
Copyright information: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.