University of Oulu

Wahab, A, Onkamo, O, Pirinen, M, Almangush, A, Salo, T. The budding and depth of invasion model in oral cancer: A systematic review and meta‐analysis. Oral Dis. 2020; 00: 1– 9. https://doi.org/10.1111/odi.13671

The budding and depth of invasion model in oral cancer : a systematic review and meta‐analysis

Saved in:
Author: Wahab, Awais1,2; Onkamo, Oona3; Pirinen, Matti4,5,6;
Organizations: 1Department of Pathology, University of Helsinki, Helsinki, Finland
2Department of Oral and Maxillofacial Diseases, University of Helsinki, Helsinki, Finland
3Cancer Research and Translational Medicine Research Unit, Faculty of Medicine, University of Oulu, Oulu, Finland
4Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland
5Department of Public Health, University of Helsinki, Helsinki, Finland
6Department of Mathematics and Statistics, University of Helsinki, Helsinki, Finland
7Research Program in Systems Oncology, Faculty of Medicine, University of Helsinki, Helsinki, Finland
8Institute of Biomedicine, Pathology, University of Turku, Turku, Finland
9Faculty of Dentistry, University of Misurata, Misurata, Libya
10Cancer and Translational Medicine Research Unit, Medical Research Center Oulu, University of Oulu and Oulu University Hospital, Oulu, Finland
Format: article
Version: accepted version
Access: embargoed
Persistent link: http://urn.fi/urn:nbn:fi-fe20201215100800
Language: English
Published: John Wiley & Sons, 2020
Publish Date: 2021-10-08
Description:

Abstract

Background: Tumour budding (B) and depth of invasion (D) have both been reported as promising prognostic markers in oral squamous cell carcinoma (OSCC). This meta‐analysis assessed the prognostic value of the tumour budding and depth of invasion combination (BD model) in OSCC.

Methods: Databases including Ovid MEDLINE, PubMed, Scopus and Web of Science were searched for articles that studied the BD model as a prognosticator in OSCC. PICO search strategy was “In OSCC patients, does BD model have a prognostic power?” We used the reporting recommendations for tumour marker prognostic studies (REMARK) criteria to evaluate the quality of studies eligible for systematic review and meta‐analysis.

Results: Nine studies were relevant as they analysed the BD model for prognostication of OSCC. These studies used either haematoxylin and eosin (HE) or pan‐cytokeratin (PCK)‐stained resected sections of OSCC. Our meta‐analysis showed a significant association of BD model with OSCC disease‐free survival (hazard ratio = 2.02; 95% confidence interval = 1.44–2.85).

Conclusions: The BD model is a simple and reliable prognostic indicator for OSCC. Evaluation of the BD model from HE‐ or PCK‐stained sections could facilitate individualized treatment planning for OSCC patients.

see all

Series: Oral diseases
ISSN: 1354-523X
ISSN-E: 1601-0825
ISSN-L: 1354-523X
Volume: In press
DOI: 10.1111/odi.13671
OADOI: https://oadoi.org/10.1111/odi.13671
Type of Publication: A2 Review article in a scientific journal
Field of Science: 3122 Cancers
Subjects:
Funding: This study was supported by a grant from the Helsinki University Hospital Research Fund, The Sigrid Juselius Foundation, and The Cancer Society of Finland.
Copyright information: © 2020 Wiley Periodicals LLC. This is the peer reviewed version of the following article: Wahab, A, Onkamo, O, Pirinen, M, Almangush, A, Salo, T. The budding and depth of invasion model in oral cancer: A systematic review and meta‐analysis. Oral Dis. 2020; 00: 1– 9, which has been published in final form at https://doi.org/10.1111/odi.13671. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.